Detalhe da pesquisa
1.
MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor.
FASEB J
; 29(5): 1817-29, 2015 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-25636740
2.
Design and synthesis of calindol derivatives as potent and selective calcium sensing receptor agonists.
Bioorg Med Chem
; 24(4): 554-69, 2016 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26752095
3.
Desert hedgehog promotes ischemia-induced angiogenesis by ensuring peripheral nerve survival.
Circ Res
; 112(5): 762-70, 2013 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23343527
4.
Sonic Hedgehog signaling is a positive oligodendrocyte regulator during demyelination.
J Neurosci
; 33(5): 1759-72, 2013 Jan 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-23365216
5.
Hedgehog-dependent regulation of angiogenesis and myogenesis is impaired in aged mice.
Arterioscler Thromb Vasc Biol
; 33(12): 2858-66, 2013 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-24135022
6.
Investigation of the proteolipid protein promoter activity during demyelination and repair.
Differentiation
; 85(4-5): 182-9, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23827460
7.
Characterization of Sonic Hedgehog transcripts in the adult mouse brain: co-expression with neuronal and oligodendroglial markers.
Brain Struct Funct
; 229(3): 705-727, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38329543
8.
Discovery, molecular and pharmacological characterization of GSA-10, a novel small-molecule positive modulator of Smoothened.
Mol Pharmacol
; 83(5): 1020-9, 2013 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-23448715
9.
Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis.
Arthritis Rheum
; 64(8): 2724-33, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22354771
10.
Hedgehog trafficking, cilia and brain functions.
Differentiation
; 83(2): S97-104, 2012 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-22169886
11.
[Structure of the Smoothened receptor]. / Structure du récepteur Smoothened.
Med Sci (Paris)
; 29(10): 855-60, 2013 Oct.
Artigo
em Francês
| MEDLINE | ID: mdl-24148123
12.
Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis.
Ann Rheum Dis
; 71(5): 785-9, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22402139
13.
Identification and mechanism of action of the acylguanidine MRT-83, a novel potent Smoothened antagonist.
Mol Pharmacol
; 79(3): 453-60, 2011 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-21177415
14.
Synthesis and biological evaluation of desmethylveramiline, a micromolar Hedgehog inhibitor.
Bioorg Med Chem Lett
; 21(12): 3608-12, 2011 Jun 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21592788
15.
[Shh signal and its functional roles in normal and diseased brain]. / Sonic Hedgehog, un morphogène en quête de fonction dans le cerveau adulte.
Med Sci (Paris)
; 27(11): 979-85, 2011 Nov.
Artigo
em Francês
| MEDLINE | ID: mdl-22130025
16.
Smoothened/AMP-Activated Protein Kinase Signaling in Oligodendroglial Cell Maturation.
Front Cell Neurosci
; 15: 801704, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-35082605
17.
Sonic Hedgehog receptor Patched deficiency in astrocytes enhances glucose metabolism in mice.
Mol Metab
; 47: 101172, 2021 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33513436
18.
Virtual screening-based discovery and mechanistic characterization of the acylthiourea MRT-10 family as smoothened antagonists.
Mol Pharmacol
; 78(4): 658-65, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20664000
19.
Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast.
Biochim Biophys Acta
; 1788(9): 1813-21, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19463780
20.
Sonic Hedgehog signaling in the mammalian brain.
J Neurochem
; 113(3): 576-90, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20218977