Detalhe da pesquisa
1.
Targeting myeloid chemotaxis to reverse prostate cancer therapy resistance.
Nature
; 623(7989): 1053-1061, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37844613
2.
Metabolomic changes of the multi (-AGC-) kinase inhibitor AT13148 in cells, mice and patients are associated with NOS regulation.
Metabolomics
; 16(4): 50, 2020 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32285223
3.
Individualized Prediction of Drug Response and Rational Combination Therapy in NSCLC Using Artificial Intelligence-Enabled Studies of Acute Phosphoproteomic Changes.
Mol Cancer Ther
; 21(6): 1020-1029, 2022 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35368084
4.
A Phase I Trial of CT900, a Novel α-Folate Receptor-Mediated Thymidylate Synthase Inhibitor, in Patients with Solid Tumors with Expansion Cohorts in Patients with High-Grade Serous Ovarian Cancer.
Clin Cancer Res
; 28(21): 4634-4641, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35984704
5.
Repurposing Vandetanib plus Everolimus for the Treatment of ACVR1-Mutant Diffuse Intrinsic Pontine Glioma.
Cancer Discov
; 12(2): 416-431, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34551970
6.
Triplet Therapy with Palbociclib, Taselisib, and Fulvestrant in PIK3CA-Mutant Breast Cancer and Doublet Palbociclib and Taselisib in Pathway-Mutant Solid Cancers.
Cancer Discov
; 11(1): 92-107, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32958578
7.
First-in-Human Study of AT13148, a Dual ROCK-AKT Inhibitor in Patients with Solid Tumors.
Clin Cancer Res
; 26(18): 4777-4784, 2020 09 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-32616501
8.
Phase I Trial of the PARP Inhibitor Olaparib and AKT Inhibitor Capivasertib in Patients with BRCA1/2- and Non-BRCA1/2-Mutant Cancers.
Cancer Discov
; 10(10): 1528-1543, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32532747
9.
ALK2 inhibitors display beneficial effects in preclinical models of ACVR1 mutant diffuse intrinsic pontine glioma.
Commun Biol
; 2: 156, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31098401
10.
Identification of 4-(4-aminopiperidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidines as selective inhibitors of protein kinase B through fragment elaboration.
J Med Chem
; 51(7): 2147-57, 2008 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-18345609
11.
An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
Cancer Chemother Pharmacol
; 62(5): 769-78, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18193424
12.
Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
Cancer Chemother Pharmacol
; 82(5): 911-912, 2018 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-30173339
13.
p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance.
Cancer Res
; 76(10): 3025-35, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27197232
14.
A phase I study of SR-4554 via intravenous administration for noninvasive investigation of tumor hypoxia by magnetic resonance spectroscopy in patients with malignancy.
Clin Cancer Res
; 9(14): 5101-12, 2003 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-14613987
15.
Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.
Cancer Cell
; 27(1): 72-84, 2015 Jan 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25533335
16.
Dual blockade of the PI3K/AKT/mTOR (AZD8055) and RAS/MEK/ERK (AZD6244) pathways synergistically inhibits rhabdomyosarcoma cell growth in vitro and in vivo.
Clin Cancer Res
; 19(21): 5940-51, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23918606
17.
Preclinical pharmacology, antitumor activity, and development of pharmacodynamic markers for the novel, potent AKT inhibitor CCT128930.
Mol Cancer Ther
; 10(2): 360-71, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-21191045
18.
A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.
Cancer Res
; 70(14): 5963-73, 2010 Jul 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20610623
19.
Discovery of 4-amino-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamides as selective, orally active inhibitors of protein kinase B (Akt).
J Med Chem
; 53(5): 2239-49, 2010 Mar 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20151677
20.
The phosphoinositide-specific phospholipase C inhibitor U73122 (1-(6-((17beta-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione) spontaneously forms conjugates with common components of cell culture medium.
Drug Metab Dispos
; 35(7): 1017-22, 2007 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-17403917