Detalhe da pesquisa
1.
The BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer.
Mol Cell
; 81(24): 4994-5006.e5, 2021 12 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34919819
2.
The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding.
PLoS Biol
; 20(12): e3001899, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36534696
3.
Inhibitors of PARP: Number crunching and structure gazing.
Proc Natl Acad Sci U S A
; 119(11): e2121979119, 2022 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-35259019
4.
PARP inhibitors trap PARP2 and alter the mode of recruitment of PARP2 at DNA damage sites.
Nucleic Acids Res
; 50(7): 3958-3973, 2022 04 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-35349716
5.
Slow Dissociation from the PARP1-HPF1 Complex Drives Inhibitor Potency.
Biochemistry
; 62(16): 2382-2390, 2023 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37531469
6.
Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.
Proc Natl Acad Sci U S A
; 116(31): 15463-15468, 2019 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31311868
7.
Probing the Conformational Changes Associated with DNA Binding to PARP1.
Biochemistry
; 59(21): 2003-2011, 2020 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32357296
8.
Q-FADD: A Mechanistic Approach for Modeling the Accumulation of Proteins at Sites of DNA Damage.
Biophys J
; 116(11): 2224-2233, 2019 06 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-31109734
9.
Nonspecific Binding of RNA to PARP1 and PARP2 Does Not Lead to Catalytic Activation.
Biochemistry
; 58(51): 5107-5111, 2019 12 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-31829559
10.
Investigating the Dynamics of Destabilized Nucleosomes Using Methyl-TROSY NMR.
J Am Chem Soc
; 140(14): 4774-4777, 2018 04 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-29589929
11.
Inhibiting transient protein-protein interactions: lessons from the Cdc25 protein tyrosine phosphatases.
Nat Rev Cancer
; 7(3): 202-11, 2007 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-17287826
12.
Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol.
Proc Natl Acad Sci U S A
; 110(24): E2182-90, 2013 Jun 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-23676275
13.
Slow inhibition and conformation selective properties of extracellular signal-regulated kinase 1 and 2 inhibitors.
Biochemistry
; 54(1): 22-31, 2015 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-25350931
14.
A radical intermediate in the conversion of pentachlorophenol to tetrachlorohydroquinone by Sphingobium chlorophenolicum.
Biochemistry
; 53(41): 6539-49, 2014 Oct 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-25238136
15.
Analyzing PARP1 Activity: Small Molecule Reactants and Attached Chains of Poly (ADP-Ribose).
Methods Mol Biol
; 2609: 61-73, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36515829
16.
Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging.
iScience
; 26(1): 105779, 2023 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-36594010
17.
HTS discovery of PARP1-HPF1 complex inhibitors in cancer.
SLAS Discov
; 28(8): 394-401, 2023 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37844763
18.
Pentachlorophenol hydroxylase, a poorly functioning enzyme required for degradation of pentachlorophenol by Sphingobium chlorophenolicum.
Biochemistry
; 51(18): 3848-60, 2012 May 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-22482720
19.
Automated modeling of protein accumulation at DNA damage sites using qFADD.py.
Biol Imaging
; 22022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36424940
20.
Histone Parylation factor 1 contributes to the inhibition of PARP1 by cancer drugs.
Nat Commun
; 12(1): 736, 2021 02 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33531508