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Hum Mol Genet ; 22(12): 2520-8, 2013 Jun 15.
Artigo em Inglês | MEDLINE | ID: mdl-23535824

RESUMO

Associations between single nucleotide polymorphisms (SNPs) at 5p15 and multiple cancer types have been reported. We have previously shown evidence for a strong association between prostate cancer (PrCa) risk and rs2242652 at 5p15, intronic in the telomerase reverse transcriptase (TERT) gene that encodes TERT. To comprehensively evaluate the association between genetic variation across this region and PrCa, we performed a fine-mapping analysis by genotyping 134 SNPs using a custom Illumina iSelect array or Sequenom MassArray iPlex, followed by imputation of 1094 SNPs in 22 301 PrCa cases and 22 320 controls in The PRACTICAL consortium. Multiple stepwise logistic regression analysis identified four signals in the promoter or intronic regions of TERT that independently associated with PrCa risk. Gene expression analysis of normal prostate tissue showed evidence that SNPs within one of these regions also associated with TERT expression, providing a potential mechanism for predisposition to disease.


Assuntos
Cromossomos Humanos Par 5/genética , Predisposição Genética para Doença , Neoplasias da Próstata/enzimologia , Neoplasias da Próstata/genética , Telomerase/genética , Adulto , Estudos de Casos e Controles , Mapeamento Cromossômico , Genótipo , Humanos , Desequilíbrio de Ligação , Masculino , Polimorfismo de Nucleotídeo Único , Regiões Promotoras Genéticas , Telomerase/metabolismo
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