Detalhe da pesquisa
1.
Wild-type sTREM2 blocks Aß aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aß aggregation.
J Biol Chem
; 296: 100631, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33823153
2.
ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1.
J Cell Sci
; 126(Pt 9): 2124-33, 2013 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23447676
3.
Ryanodine receptor blockade reduces amyloid-ß load and memory impairments in Tg2576 mouse model of Alzheimer disease.
J Neurosci
; 32(34): 11820-34, 2012 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-22915123
4.
Further characterization of a putative serine protease contributing to the γ-secretase cleavage of ß-amyloid precursor protein.
Bioorg Med Chem
; 21(4): 1018-29, 2013 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23294826
5.
p53-dependent control of transactivation of the Pen2 promoter by presenilins.
J Cell Sci
; 122(Pt 21): 4003-8, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19889971
6.
Aminopeptidase A contributes to the N-terminal truncation of amyloid beta-peptide.
J Neurochem
; 109(1): 248-56, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19187443
7.
Pharmacological evidences for DFK167-sensitive presenilin-independent gamma-secretase-like activity.
J Neurochem
; 110(1): 275-83, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19457123
8.
TMP21 regulates Abeta production but does not affect caspase-3, p53, and neprilysin.
Biochem Biophys Res Commun
; 371(1): 69-74, 2008 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-18405662
9.
Presenilin-dependent gamma-secretase-mediated control of p53-associated cell death in Alzheimer's disease.
J Neurosci
; 26(23): 6377-85, 2006 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16763046
10.
The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.
Curr Alzheimer Res
; 4(4): 423-6, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17908046
11.
A ZIP6-ZIP10 heteromer controls NCAM1 phosphorylation and integration into focal adhesion complexes during epithelial-to-mesenchymal transition.
Sci Rep
; 7: 40313, 2017 01 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28098160
12.
TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
EMBO Mol Med
; 9(10): 1366-1378, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28855301
13.
Parkin differently regulates presenilin-1 and presenilin-2 functions by direct control of their promoter transcription.
J Mol Cell Biol
; 5(2): 132-42, 2013 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-23359614
14.
Evidence that the amyloid-ß protein precursor intracellular domain, AICD, derives from ß-secretase-generated C-terminal fragment.
J Alzheimers Dis
; 30(1): 145-53, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22406447
15.
APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexes.
J Biol Chem
; 284(24): 16298-16307, 2009 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-19369254
16.
NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.
J Biol Chem
; 283(15): 10037-47, 2008 Apr 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18263584
17.
p53-Dependent Aph-1 and Pen-2 anti-apoptotic phenotype requires the integrity of the gamma-secretase complex but is independent of its activity.
J Biol Chem
; 282(14): 10516-25, 2007 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-17276981
18.
Response to correspondence: Pardossi-Piquard et al., "Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betAAPP and APLP." Neuron 46, 541-554.
Neuron
; 53(4): 483-6, 2007 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-17296550