RESUMO
Cerebellar abiotrophy (CA) is a degenerative disorder of the central nervous system (CNS) that has been reported in humans and animals. In cattle, CA had been reported in Bos taurus taurus and crossbreed cattle. CA is characterized by degeneration and loss of Purkinje cells and decrease in the population of granule cells. The pathogenesis of this process is unknown, but it is believed that there is an autosomal recessive heritable factor involved. A 15-month-old Nelore ox (Bos taurus indicus) was sent to a slaughterhouse, where it presented cerebellar ataxia, symmetrical hypermetria, spasticity, ptyalism, and incoordination. There were no macroscopic changes. CNS samples were negative for BSE, rabies, and other infectious pathogens. Microscopically, there was atrophy of the molecular, granular, and Purkinje cell layers of the cerebellar cortex, and a marked and diffuse loss of the Purkinje cells. No other microscopic lesions were observed in CNS. These findings were consistent with cerebellar abiotrophy. To the best of our knowledge, no cases of CA have ever been reported in Bos taurus indicus. Therefore, the present case of CA in Nelore is the first report of the disease in Zebu cattle.
RESUMO
The purpose of this paper is to establish criteria that could guide the diagnosis, prognosis and treatment of canine mammary neoplasias. It was elaborated during the Mammary Pathology Meeting: Diagnosis, Prognosis and Treatment of the Canine Mammary Neoplasm, held on November 6th and 7th, 2010 in Belo Horizonte MG, Brazil, sponsored by the Laboratory of Comparative Pathology UFMG, with the support of the Brazilian Association of Veterinary Pathology (ABPV) and Brazilian Association of Veterinary Oncology (ABROVET). Academics from several regions of Brazil were present and contributed to this work.