Detalhe da pesquisa
1.
Key bioactive reaction products of the NO/H2S interaction are S/N-hybrid species, polysulfides, and nitroxyl.
Proc Natl Acad Sci U S A
; 112(34): E4651-60, 2015 Aug 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26224837
2.
The nitric oxide donor JS-K sensitizes U87 glioma cells to repetitive irradiation.
Tumour Biol
; 39(6): 1010428317703922, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28653883
3.
Hepatoselective Nitric Oxide (NO) Donors, V-PYRRO/NO and V-PROLI/NO, in Nonalcoholic Fatty Liver Disease: A Comparison of Antisteatotic Effects with the Biotransformation and Pharmacokinetics.
Drug Metab Dispos
; 43(7): 1028-36, 2015 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-25870102
4.
PABA/NO lead optimization: Improved targeting of cytotoxicity to glutathione S-transferase P1-overexpressing cancer cells.
Bioorg Med Chem
; 23(15): 4980-4988, 2015 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26043946
5.
Direct reaction of amides with nitric oxide to form diazeniumdiolates.
J Org Chem
; 79(19): 9389-93, 2014 Oct 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-25210948
6.
Aminolysis of an N-diazeniumdiolated amidine as an approach to diazeniumdiolated ammonia.
J Org Chem
; 79(10): 4512-6, 2014 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-24766285
7.
Enzymatic generation of the NO/HNO-releasing IPA/NO anion at controlled rates in physiological media using ß-galactosidase.
Nitric Oxide
; 35: 131-6, 2013 Nov 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-24126017
8.
Effects of the nitric oxide donor JS-K on the blood-tumor barrier and on orthotopic U87 rat gliomas assessed by MRI.
Nitric Oxide
; 30: 17-25, 2013 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-23370169
9.
Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-π-activated nitric oxide donor PABA/NO in malignant gliomas.
Int J Cancer
; 130(5): 1184-94, 2012 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21455987
10.
Cross-linking protein glutathionylation mediated by O2-arylated bis-diazeniumdiolate "Double JS-K".
Chem Res Toxicol
; 25(12): 2670-7, 2012 Dec 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-23106594
11.
O2-functionalized methylamine diazeniumdiolates: evidence for E â Z equilibration in an acyclic system.
J Org Chem
; 77(23): 10804-10, 2012 Dec 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-23137026
12.
Diazeniumdiolated carbamates: a novel class of nitric oxide donors.
Bioorg Med Chem
; 20(6): 2025-9, 2012 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-22356735
13.
Structural modifications modulate stability of glutathione-activated arylated diazeniumdiolate prodrugs.
Bioorg Med Chem
; 20(9): 3094-9, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22480849
14.
The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen species.
J Pharmacol Exp Ther
; 336(2): 313-20, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20962031
15.
HNO and NO release from a primary amine-based diazeniumdiolate as a function of pH.
Inorg Chem
; 50(8): 3262-70, 2011 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-21405089
16.
Dual mechanisms of HNO generation by a nitroxyl prodrug of the diazeniumdiolate (NONOate) class.
J Am Chem Soc
; 132(46): 16526-32, 2010 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-21033665
17.
Insulin enhances the effect of nitric oxide at inhibiting neointimal hyperplasia in a rat model of type 1 diabetes.
Am J Physiol Heart Circ Physiol
; 299(3): H772-9, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20562340
18.
Isopropylamine NONOate (IPA/NO) moderates neointimal hyperplasia following vascular injury.
J Vasc Surg
; 51(5): 1248-59, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20223627
19.
Stabilization of the nitric oxide (NO) prodrugs and anticancer leads, PABA/NO and Double JS-K, through incorporation into PEG-protected nanoparticles.
Mol Pharm
; 7(1): 291-8, 2010 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20000791
20.
Gene expression profiling for nitric oxide prodrug JS-K to kill HL-60 myeloid leukemia cells.
Genomics
; 94(1): 32-8, 2009 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-19348908