Detalhe da pesquisa
1.
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.
Proc Natl Acad Sci U S A
; 120(1): e2211297120, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36574664
2.
Drugging an undruggable pocket on KRAS.
Proc Natl Acad Sci U S A
; 116(32): 15823-15829, 2019 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31332011
3.
Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex.
Biochemistry
; 59(8): 964-969, 2020 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32032490
4.
Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers.
Proc Natl Acad Sci U S A
; 117(7): 3365-3367, 2020 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32047042
5.
The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo.
BMC Cancer
; 17(1): 88, 2017 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-28143493
6.
Adaptor protein2 (AP2) orchestrates CXCR2-mediated cell migration.
Traffic
; 15(4): 451-69, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24450359
7.
Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors.
J Med Chem
; 66(24): 16783-16806, 2023 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38085679
8.
Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization.
J Med Chem
; 65(8): 6287-6312, 2022 04 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-35436124
9.
Bimodal analysis reveals a general scaling law governing nondirected and chemotactic cell motility.
Biophys J
; 99(2): 367-76, 2010 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-20643054
10.
Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods.
J Med Chem
; 63(15): 8325-8337, 2020 08 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-32673492
11.
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
J Med Chem
; 63(2): 656-675, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31858797
12.
Short tail with skin lesion phenotype occurs in transgenic mice with keratin-14 promoter-directed expression of mutant CXCR2.
J Leukoc Biol
; 84(2): 406-19, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18505935
13.
Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses.
ACS Chem Biol
; 14(3): 325-331, 2019 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30735352
14.
Discovery and Optimization of Salicylic Acid-Derived Sulfonamide Inhibitors of the WD Repeat-Containing Protein 5-MYC Protein-Protein Interaction.
J Med Chem
; 62(24): 11232-11259, 2019 12 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-31724864
15.
Chemokine receptor internalization and intracellular trafficking.
Cytokine Growth Factor Rev
; 16(6): 637-58, 2005 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-15998596
16.
Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design.
J Med Chem
; 61(13): 5623-5642, 2018 07 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-29889518
17.
Discovery of Aminopiperidine Indoles That Activate the Guanine Nucleotide Exchange Factor SOS1 and Modulate RAS Signaling.
J Med Chem
; 61(14): 6002-6017, 2018 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-29856609
18.
Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
J Med Chem
; 61(19): 8875-8894, 2018 10 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30205005
19.
Rab11-family interacting protein 2 and myosin Vb are required for CXCR2 recycling and receptor-mediated chemotaxis.
Mol Biol Cell
; 15(5): 2456-69, 2004 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-15004234
20.
PI3K Inhibition Reduces Mammary Tumor Growth and Facilitates Antitumor Immunity and Anti-PD1 Responses.
Clin Cancer Res
; 23(13): 3371-3384, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28003307