Relationship between molar occlusion and masticatory movement in lateral deviation of the mandible.

INTRODUCTION: The relationship between molar occlusion and chewing patterns was examined in subjects with laterally deviated mandibles. METHODS: Twenty-three patients with mandibular deviation from the midline (4 mm or more) and skeletal Class I (0° ≤ANB ≤4°) were divided into 2 groups: normal bite and crossbite. The chewing pattern was classified as normal, reversed, or crossover. RESULTS: The normal bite group had a normal chewing pattern on the affected side 100% of the time and a reversed chewing pattern on the affected and unaffected sides 0% and 7.2% of the time, respectively. Additionally, the normal bite group showed no evidence of a crossover chewing pattern and also had significantly less axial inclination of the mandibular teeth on the affected side compared with the crossbite group; lingual inclination was also evident. The crossbite group had a normal chewing pattern on the affected and unaffected sides 0% and 55.6% of the time, respectively, and reversed and crossover chewing patterns on the affected side 55.6% and 44.4% of the time, respectively. CONCLUSIONS: A normal chewing pattern tends to result in lingual axial inclination of the mandibular molars on the affected side, as well as a more consistent chewing pattern.

[Nab-Paclitaxel with platinum chemotherapy as sixth-line therapy for a non-small cell lung cancer patient].

A 48-year-old woman was admitted to our hospital for sixth-line chemotherapy. A chest X-ray film and computed tomographic (CT) scan revealed a right-sided massive tumor with multiple lung tumors. Repeated treatment with carboplatin (AUC 6) on day 1 and nab-paclitaxel (100mg/m2) on days 1, 8, and 15, every 28 days were effective in this patient. Chemotherapy with nab-paclitaxel may be effective for patients with multi-recurrent adenocarcinoma.

A Case of Dedifferentiated Melanoma With Lymph Node Metastasis Where Molecular Biological Tests Were Useful for Diagnosis.

Malignant melanoma is known to have an altered phenotype and loss of differentiation markers for melanoma due to metastasis. Here, we report a case in which the expression of the immunohistochemical markers for melanoma was changed due to lymph node metastasis of primary cutaneous malignant melanoma. The patient, a male in his 60s, was diagnosed with malignant melanoma after undergoing excision of a skin mass. The additional excision specimen showed a small number of tumor cell clusters infiltrating the dermis. The biopsied lymph node showed completely different histological findings from those of the skin lesion and consisted of spindle-shaped tumor cells. An immunohistochemical study revealed no significant positive reactions in the lymph node tissue indicative of melanoma. The additional genetic study revealed BRAF V600e mutations in both the primary tumor and a lymph node. Together with the histological findings, the diagnosis was of metastasis of dedifferentiated melanoma to a lymph node. In summary, there is a risk of underestimation or misdiagnosis of melanoma as undifferentiated sarcoma or other tumors when melanoma metastasizes to lymph nodes and findings show a dedifferentiated or undifferentiated tumor. Therefore, as in this case, it is necessary to add a genetic study in order to make a comprehensive judgment.

[Bevacizumab with platinum chemotherapy as 6th-line treatment in a case of non-small-cell lung cancer].

A 64-year-old man was admitted to our hospital for 6th-line chemotherapy. Chest X-ray film and computed tomographic (CT) scan showed right-sided pleural thickening with multiple lung tumors. Repeated treatment with carboplatin (AUC 6), paclitaxel (200 mg/m(2)) and bevacizumab (150 mg/kg) on day 1 every 21 days was effective for this patient. Chemotherapy with bevacizumab may be effective for patients with multi-recurrent adenocarcinoma.

Long-term changes in pharyngeal airway morphology after mandibular setback surgery.

Long-term changes in pharyngeal airway morphology were evaluated after mandibular setback surgery in 10 women who were diagnosed as having skeletal mandibular prognathism and underwent mandibular setback surgery by bilateral sagittal split ramus osteotomy (SSRO) and orthodontic multi-bracket treatment. The subjects were assessed before treatment (T1), 3-6 months after SSRO (T2), and 2 or more years after SSRO (T3). From T1 to T2, the pharyngeal airway constricted significantly. On the other hand, from T2 to T3, the lower facial morphology showed no significant changes. The pharyngeal airway morphology showed significant changes in soft-palate length and posterior reference line to point of posterior tongue, indicating a tendency for relapse. These results suggest that, although the lower facial morphology and the pharyngeal airway morphology showed marked changes after SSRO, the pharyngeal airway morphology exhibited gradual physiologic readaptation. However, because the lower facial morphology after surgery was retained and stable for a long period, it was considered normal for the pharyngeal airway morphology to adapt after surgery to the improved hard tissue relationship.