Detalhe da pesquisa
1.
Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6.
Proc Natl Acad Sci U S A
; 119(32): e2201483119, 2022 08 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35930668
2.
Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling.
Bioorg Med Chem
; 99: 117597, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38262305
3.
Structural coupling of SH2-kinase domains links Fes and Abl substrate recognition and kinase activation.
Cell
; 134(5): 793-803, 2008 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-18775312
4.
Conformational plasticity of the ULK3 kinase domain.
Biochem J
; 478(14): 2811-2823, 2021 07 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34190988
5.
Fluorinated derivatives of pyridine-2,4-dicarboxylate are potent inhibitors of human 2-oxoglutarate dependent oxygenases.
J Fluor Chem
; 247: 109804, 2021 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-34219804
6.
Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy.
Nature
; 508(7495): 222-7, 2014 Apr 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-24695225
7.
Lessons from LIMK1 enzymology and their impact on inhibitor design.
Biochem J
; 476(21): 3197-3209, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31652302
8.
Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1.
Biochemistry
; 57(14): 2140-2149, 2018 04 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29558110
9.
Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation.
Chem Sci
; 15(20): 7667-7678, 2024 May 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38784729
10.
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate.
J Med Chem
; 67(6): 4525-4540, 2024 Mar 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38294854
11.
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia.
Nat Cancer
; 2024 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38637657
12.
Correction to "Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID subunit 1".
Biochemistry
; 57(49): 6806, 2018 12 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-30485080
13.
Structure of the CaMKIIdelta/calmodulin complex reveals the molecular mechanism of CaMKII kinase activation.
PLoS Biol
; 8(7): e1000426, 2010 Jul 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-20668654
14.
Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5.
RSC Chem Biol
; 4(6): 399-413, 2023 Jun 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-37292060
15.
The catalytic domains of all human KDM5 JmjC demethylases catalyse N-methyl arginine demethylation.
FEBS Lett
; 597(7): 933-946, 2023 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-36700827
16.
Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals.
Commun Chem
; 6(1): 12, 2023 Jan 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-36698022
17.
Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66.
RSC Chem Biol
; 4(3): 235-243, 2023 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36908702
18.
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5.
J Med Chem
; 66(15): 10849-10865, 2023 08 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-37527664
19.
Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α.
Chem Sci
; 14(43): 12098-12120, 2023 Nov 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37969593
20.
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine.
J Med Chem
; 66(4): 2663-2680, 2023 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-36757959