Effect of the inhibitor peptide of the transforming growth factor beta (p144) in a new silicone pericapsular fibrotic model in pigs.

BACKGROUND: Capsular contracture is the most common complication associated with silicone prostheses. It may take the form of anything from slight hardening to obvious deformity. The role of transforming growth factor beta (TGF-beta) in the scar physiopathology of any fibrotic process has been demonstrated. The effects of inhibition of TGF-beta have also been demonstrated in experimental models of fibrosis, which opens the way for new therapeutic alternatives in the treatment of capsular contracture. The aim of this study was to evaluate periprosthetic fibrosis with a newly synthesized TGF-beta peptide inhibitor (p144). METHODS: Three experimental groups were formed: Group I, subcutaneous and submuscular textured silicone prostheses were left untreated; Group 2, the prostheses were left after being immersed in the vehicle; Group 3, the same protocol was followed as in Group 2, but the solution contained the vehicle with the inhibitor peptide of TGF-beta, p144 (15 mg/prosthesis). The animals were sacrificed 24 weeks after implantation, and the capsules were assessed both macroscopically and histologically. RESULTS: The results obtained showed that the inhibition of capsular thickness and soluble collagen content in pericapsular fibrosis did not significantly decrease in the group of animals treated with the TGF-beta inhibitor peptide in comparison with control cases. CONCLUSIONS: We detected no statistically significant reduction in fibrosis in the periprosthetic capsule after treating the implants with the inhibitor peptide p144, but we feel that the influence of trauma around the prosthesis is critical in impeding the antifibrotic activity of the inhibitor peptide.

[Association between eating behavior and nutritional status in Chilean preschoolers]. / Asociación entre conducta alimentaria y estado nutricional en preescolares chilenos.

INTRODUCCIÓN: the eating behavior is associated with the nutritional status at early ages. However, in Chile there are still no studies that evaluate this relationship in the preschool stage. OBJECTIVE: to associate the nutritional status and eating behavior of Chilean preschoolers. METHODS: cross-sectional study in 247 preschoolers (2-4 years) from the region of Araucanía, Chile. The nutritional status was evaluated through the anthropometric index weight/height and waist circumference/age. The Child Eating Behavior Questionnaire (CEBQ) survey was applied to mothers to assess their children's eating. RESULTS: one hundred and thirty were men and 117 were women with an overweight/obese percentage of 58.6% and 49.6%, respectively. Eating behavior scores pro-intake (food approach) have a positive and significant association with nutritional status) and in the food responsiveness sub-scale in the total sample. Regarding the anti-intake score (food avoidant), an inverse trend with nutritional status is shown; however, there is a negative and significant association in the satiety responsiveness scale and slowness in eating. CONCLUSION: the pro-intake eating behavior is directly associated with nutritional status, and anti-ingest score is inversely related only to certain sub-scales.

INTRODUCCIÓN: la conducta alimentaria se asocia con el estado nutricional en edades tempranas. Sin embargo, en Chile aún no existen estudios que evalúen esta relación en la etapa preescolar. OBJETIVO: asociar el estado nutricional y la conducta alimentaria de preescolares chilenos. MÉTODO: estudio de corte transversal en 247 preescolares (2-4 años) de la Región de la Araucanía, Chile. Se evaluó el estado nutricional a través del índice antropométrico peso/talla y perímetro de cintura/edad. Se aplicó la encuesta Child Eating Behaviour Questionnaire (CEBQ) a las madres para evaluar la conducta alimentaria de sus hijos. RESULTADOS: ciento treinta fueron hombres y 117 fueron mujeres, con una malnutrición por exceso del 58,6% y 49,6%, respectivamente. Las puntuaciones de conducta alimentaria (CA) proingesta presentaron una asociación positiva y significativa con el estado nutricional y la dimensión respuesta a los alimentos. En cuanto a las puntuaciones de CA antiingesta, se observó una tendencia inversa no significativa con el estado nutricional; sin embargo, existe una asociación negativa y significativa en las dimensiones respuesta a la saciedad y lentitud para comer. CONCLUSIÓN: la conducta alimentaria proingesta se asocia directamente con el estado nutricional y la conducta antiingesta, de manera inversa solo con ciertas dimensiones.

Asociación entre conducta alimentaria y estado nutricional en preescolares chilenos / Association between eating behavior and nutritional status in Chilean preschoolers

Introducción: la conducta alimentaria se asocia con el estado nutricional en edades tempranas. Sin embargo, en Chile aún no existen estudios que evalúen esta relación en la etapa preescolar. Objetivo: asociar el estado nutricional y la conducta alimentaria de preescolares chilenos. Método: estudio de corte transversal en 247 preescolares (2-4 años) de la Región de la Araucanía, Chile. Se evaluó el estado nutricional a través del índice antropométrico peso/talla y perímetro de cintura/edad. Se aplicó la encuesta Child Eating Behaviour Questionnaire (CEBQ) a las madres para evaluar la conducta alimentaria de sus hijos. Resultados: ciento treinta fueron hombres y 117 fueron mujeres, con una malnutrición por exceso del 58,6% y 49,6%, respectivamente. Las puntuaciones de conducta alimentaria (CA) proingesta presentaron una asociación positiva y significativa con el estado nutricional y la dimensión respuesta a los alimentos. En cuanto a las puntuaciones de CA antiingesta, se observó una tendencia inversa no significativa con el estado nutricional; sin embargo, existe una asociación negativa y significativa en las dimensiones respuesta a la saciedad y lentitud para comer. Conclusión: la conducta alimentaria proingesta se asocia directamente con el estado nutricional y la conducta antiingesta, de manera inversa solo con ciertas dimensiones

Introduction: the eating behavior is associated with the nutritional status at early ages. However, in Chile there are still no studies that evaluate this relationship in the preschool stage. Objective: to associate the nutritional status and eating behavior of Chilean preschoolers. Methods: cross-sectional study in 247 preschoolers (2-4 years) from the region of Araucanía, Chile. The nutritional status was evaluated through the anthropometric index weight/height and waist circumference/age. The Child Eating Behavior Questionnaire (CEBQ) survey was applied to mothers to assess their children’s eating. Results: one hundred and thirty were men and 117 were women with an overweight/obese percentage of 58.6% and 49.6%, respectively. Eating behavior scores pro-intake (food approach) have a positive and significant association with nutritional status) and in the food responsiveness sub-scale in the total sample. Regarding the anti-intake score (food avoidant), an inverse trend with nutritional status is shown; however, there is a negative and significant association in the satiety responsiveness scale and slowness in eating. Conclusion: the pro-intake eating behavior is directly associated with nutritional status, and anti-ingest score is inversely related only to certain sub-scales