Detalhe da pesquisa
1.
A phase Ib open-label dose escalation study of the safety, pharmacokinetics, and pharmacodynamics of cobimetinib (GDC-0973) and ipatasertib (GDC-0068) in patients with locally advanced or metastatic solid tumors.
Invest New Drugs
; 39(1): 163-174, 2021 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-32737717
2.
[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer's disease.
Eur J Nucl Med Mol Imaging
; 46(10): 2077-2089, 2019 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-31254035
3.
Characterization of the novel GlyT1 PET tracer [18F]MK-6577 in humans.
Synapse
; 69(1): 33-40, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25196464
4.
Evaluation of partial volume correction and analysis of longitudinal [18F]GTP1 tau PET imaging in Alzheimer's disease using linear mixed-effects models.
Front Neuroimaging
; 3: 1355402, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38606196
5.
The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.
Cell Metab
; 7(1): 68-78, 2008 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-18177726
6.
Evaluation of [¹8F]MK-0911, a positron emission tomography (PET) tracer for opioid receptor-like 1 (ORL1), in rhesus monkey and human.
Neuroimage
; 68: 1-10, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23238431
7.
In vivo quantification of calcitonin gene-related peptide receptor occupancy by telcagepant in rhesus monkey and human brain using the positron emission tomography tracer [11C]MK-4232.
J Pharmacol Exp Ther
; 347(2): 478-86, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23975906
8.
GTP1 metabolic stability assessment: A study of the tau PET tracer [18F]GTP1.
Nucl Med Biol
; 124-125: 108386, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37699300
9.
Randomized Phase II Study of the Safety and Efficacy of Semorinemab in Participants With Mild-to-Moderate Alzheimer Disease: Lauriet.
Neurology
; 101(14): e1391-e1401, 2023 10 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37643887
10.
Quantification of the glycine transporter 1 in rhesus monkey brain using [18F]MK-6577 and a model-based input function.
Neuroimage
; 59(3): 2589-99, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21930214
11.
Site-Specific Cerebrospinal Fluid Tau Hyperphosphorylation in Response to Alzheimer's Disease Brain Pathology: Not All Tau Phospho-Sites are Hyperphosphorylated.
J Alzheimers Dis
; 85(1): 415-429, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-34806603
12.
Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials.
JAMA Neurol
; 79(11): 1113-1121, 2022 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36121669
13.
Safety and Efficacy of Semorinemab in Individuals With Prodromal to Mild Alzheimer Disease: A Randomized Clinical Trial.
JAMA Neurol
; 79(8): 758-767, 2022 08 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35696185
14.
Whole-body CD8+ T cell visualization before and during cancer immunotherapy: a phase 1/2 trial.
Nat Med
; 28(12): 2601-2610, 2022 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-36471036
15.
Neuropeptide Y5 receptor antagonism does not induce clinically meaningful weight loss in overweight and obese adults.
Cell Metab
; 4(4): 275-82, 2006 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-17011500
16.
Synthesis, characterization, and monkey positron emission tomography (PET) studies of [18F]Y1-973, a PET tracer for the neuropeptide Y Y1 receptor.
Neuroimage
; 54(4): 2635-42, 2011 Feb 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21078401
17.
Synthesis, characterization, and monkey PET studies of [¹8F]MK-1312, a PET tracer for quantification of mGluR1 receptor occupancy by MK-5435.
Synapse
; 65(2): 125-35, 2011 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-20524178
18.
The synthesis and preclinical evaluation in rhesus monkey of [¹8F]MK-6577 and [¹¹C]CMPyPB glycine transporter 1 positron emission tomography radiotracers.
Synapse
; 65(4): 261-70, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20687108
19.
Baseline [18F]GTP1 tau PET imaging is associated with subsequent cognitive decline in Alzheimer's disease.
Alzheimers Res Ther
; 13(1): 196, 2021 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34852837
20.
Kinetic analysis of the cannabinoid-1 receptor PET tracer [(18)F]MK-9470 in human brain.
Eur J Nucl Med Mol Imaging
; 37(5): 920-33, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20033684