Detalhe da pesquisa
1.
Deciphering the super relaxed state of human ß-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers.
Proc Natl Acad Sci U S A
; 115(35): E8143-E8152, 2018 08 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-30104387
2.
Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human ß-cardiac myosin.
J Exp Biol
; 219(Pt 2): 161-7, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26792326
3.
The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin.
Sci Adv
; 6(14): eaax0069, 2020 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32284968
4.
ß-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity.
Nat Commun
; 10(1): 2685, 2019 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-31213605
5.
Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light.
Biophys Rev
; 10(1): 27-48, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-28717924
6.
Biophysical properties of human ß-cardiac myosin with converter mutations that cause hypertrophic cardiomyopathy.
Sci Adv
; 3(2): e1601959, 2017 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-28246639
7.
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations.
Nat Struct Mol Biol
; 24(6): 525-533, 2017 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-28481356
8.
Early-Onset Hypertrophic Cardiomyopathy Mutations Significantly Increase the Velocity, Force, and Actin-Activated ATPase Activity of Human ß-Cardiac Myosin.
Cell Rep
; 17(11): 2857-2864, 2016 12 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-27974200