Detalhe da pesquisa
1.
Antitarget Selectivity and Tolerability of Novel Pyrrolo[2,3-d]pyrimidine RET Inhibitors.
ACS Med Chem Lett
; 12(12): 1912-1919, 2021 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34917254
2.
Efficacy and Tolerability of Pyrazolo[1,5-a]pyrimidine RET Kinase Inhibitors for the Treatment of Lung Adenocarcinoma.
ACS Med Chem Lett
; 11(4): 558-565, 2020 Apr 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-32292564
3.
Synthesis, structure-activity relationships, and in vivo efficacy of the novel potent and selective anaplastic lymphoma kinase (ALK) inhibitor 5-chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) currently in phase 1 and phase 2 clinical trials.
J Med Chem
; 56(14): 5675-90, 2013 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-23742252
4.
Discovery of GNF-5837, a Selective TRK Inhibitor with Efficacy in Rodent Cancer Tumor Models.
ACS Med Chem Lett
; 3(2): 140-5, 2012 Feb 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-24900443