Detalhe da pesquisa
1.
Preclinical pharmacokinetic exploration of a novel osteoporotic quinazolinone-benzopyran-indole hybrid (S019-0385) using LC-MS/MS.
Xenobiotica
; 53(6-7): 484-497, 2023 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-37787761
2.
Benzofuran pyran hybrid prevents glucocorticoid induced osteoporosis in mice via modulation of canonical Wnt/ß-catenin signaling.
Apoptosis
; 27(1-2): 90-111, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35107658
3.
Microwave-assisted efficient synthesis of pyrazole-fibrate derivatives as stimulators of glucose uptake in skeletal muscle cells.
Bioorg Med Chem Lett
; 34: 127760, 2021 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33359606
4.
Synthesis, biological evaluation and molecular dynamic simulations of novel Benzofuran-tetrazole derivatives as potential agents against Alzheimer's disease.
Bioorg Med Chem Lett
; 29(1): 66-72, 2019 01 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30455151
5.
Benzofuran-pyran hybrids: A new class of potential bone anabolic agents.
Bioorg Med Chem Lett
; 28(10): 1719-1724, 2018 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29703629
6.
In-house chemical library repurposing: A case example for Pseudomonas aeruginosa antibiofilm activity and quorum sensing inhibition.
Drug Dev Res
; 79(8): 383-390, 2018 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-30291767
7.
Down-regulation of PE11, a cell wall associated esterase, enhances the biofilm growth of Mycobacterium tuberculosis and reduces cell wall virulence lipid levels.
Microbiology (Reading)
; 163(1): 52-61, 2017 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28198348
8.
Benzofuran-dihydropyridine hybrids: A new class of potential bone anabolic agents.
Bioorg Med Chem
; 25(24): 6450-6466, 2017 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-29097030
9.
Design and synthesis of new series of coumarin-aminopyran derivatives possessing potential anti-depressant-like activity.
Bioorg Med Chem Lett
; 25(2): 337-41, 2015 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25488839
10.
Anti-tumour activity of a novel coumarin-chalcone hybrid is mediated through intrinsic apoptotic pathway by inducing PUMA and altering Bax/Bcl-2 ratio.
Apoptosis
; 19(6): 1017-28, 2014 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-24638227
11.
Induction of mitochondrial dysfunction and oxidative stress in Leishmania donovani by orally active clerodane diterpene.
Antimicrob Agents Chemother
; 58(10): 5916-28, 2014 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-25070112
12.
Synthesis and evaluation of new 3-phenylcoumarin derivatives as potential antidepressant agents.
Bioorg Med Chem Lett
; 24(20): 4876-80, 2014 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25239852
13.
Androsin alleviates non-alcoholic fatty liver disease by activating autophagy and attenuating de novo lipogenesis.
Phytomedicine
; 129: 155702, 2024 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-38749344
14.
Synergy between human DNA ligase I and topoisomerase 1 unveils new therapeutic strategy for the management of colorectal cancer.
J Biomol Struct Dyn
; : 1-16, 2024 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-38179981
15.
16-Hydroxy-ent-halima-5(10),13-dien-15,16-olide from Polyalthia longifolia targets adipogenesis by inhibiting mitotic clonal expansion and ameliorates dyslipidemia.
Fitoterapia
; 170: 105626, 2023 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-37516404
16.
Moringa oleifera impedes protein glycation and exerts reno-protective effects in streptozotocin-induced diabetic rats.
J Ethnopharmacol
; 305: 116117, 2023 Apr 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-36584917
17.
Design, synthesis and evaluation of novel pyrrole-hydroxybutenolide hybrids as promising antiplasmodial and anti-inflammatory agents.
Eur J Med Chem
; 254: 115340, 2023 Jun 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37054559
18.
Discovery, SAR and mechanistic studies of quinazolinone-based acetamide derivatives in experimental visceral leishmaniasis.
Eur J Med Chem
; 257: 115524, 2023 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-37290183
19.
A standardized extract of Coleus forskohlii root protects rats from ovariectomy-induced loss of bone mass and strength, and impaired bone material by osteogenic and anti-resorptive mechanisms.
Front Endocrinol (Lausanne)
; 14: 1130003, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-36926021
20.
Antileishmanial evaluation of triazole-butenolide conjugates: design, synthesis, in vitro screening, SAR and in silico ADME predictions.
RSC Med Chem
; 14(6): 1131-1142, 2023 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-37360388