Identifying predictors of blood pressure control in the Lebanese population - a national, multicentric survey -- I-PREDICT.

BACKGROUND: Blood Pressure (BP) is not well controlled and factors that predict BP control are not well identified in Lebanon. Improvement of hypertension management requires an understanding of patients' characteristics and factors associated with uncontrolled BP. This national, multicentric, observational prospective study was designed to determine the predictors of BP control in patients followed up to 6 months. METHODS: I-PREDICT study was conducted on 988 patients with newly diagnosed or uncontrolled hypertension. Socio-demographic and clinical characteristics were analyzed. The level of agreement between doctors' perceptions on BP control status and JNC VII guidelines was analyzed. RESULTS: The predictor associated with poor BP control was diabetes (OR = 0.17, CI = 0.10-0.28 at month-1; OR = 0.15, CI = 0.10-0.24 at month-6). The predictors associated with better BP control at month-6 were the early control of BP at month-1 (OR = 10.39, CI = 6.18-17.47) and combination therapy prescribed at baseline and month-1 (OR = 15.14, CI = 1.09-208.46, P = 0.04). In the sub-group of diabetes, the predictors that were associated with better BP control at 6 months were following diet at V1 (OR = 2.27, CI = 1.01 to 5.12) and BP control at V2 (OR = 7.34, CT = 3.83 to 14.07). The predictors that were associated with poor BP control at 6 months were middle economic class (OR = 0.036, CI = 0.16-0.94) and upper economic class (OR = 0.036; CI = 0.13-0.93).The rate of BP control was significantly higher at month 6 versus month 1 (67.52% vs 44.08%, P = 0.001). Additional analysis showed poor agreement between the doctors' perceptions on BP control status and the guidelines. CONCLUSIONS: Reaching an early BP control and combination therapy were significant predictors of better BP control, whereas diabetes was a significant predictor of poor BP control. A poor agreement between JNC VII guidelines and clinical practice was observed. I-PREDICT study identified factors that can be targeted for improving BP control.

Management and control of patients with type 2 diabetes mellitus in Lebanon: results from the International Diabetes Management Practices Study (IDMPS).

BACKGROUND: The IDMPS is a study to identify changes in diabetes treatment practice in several developing countries. This paper focuses on diabetes management and compliance with guidelines in a Middle Eastern country like Lebanon. METHODS: The cross-sectional data from the 2006 wave of two weeks duration on the Lebanese population along with the longitudinal data of a 9-month follow-up study were collected. RESULTS: A large proportion of Lebanese patients were not adequately controlled or followed up. A slight proportion was managed by diet and exercise alone while most patients were on two or more oral anti-hyperglycemics. Metformin was the most common monotherapy followed by sulfonylureas. 22.6% of Lebanese patients were on insulin, most commonly basal insulin alone followed by premix insulin alone. Blood glucose self-monitoring was more frequently done by insulinized patients and was associated with better glycemic control. Glycemic control was reached in 29.6% of type 2 patients (HbA1c < 7%) with poorest outcome for patients on insulin and was more frequently achieved in patients who had more frequent monitoring of HbA1c levels. CONCLUSION: For a proper assessment of diabetic control, maintaining adherence to international guidelines needs to be evaluated. Promoting patient education, improving physician knowledge with better implementation of guidelines is recommended.

Management and control of type 2 diabetes mellitus in Lebanon: Results from the International Diabetes Management Practices Study Wave 6.

BACKGROUND: Diabetes mellitus is a worldwide public health problem associated with significant complications. There is lack of data on the quality of care of patients with diabetes, specifically among the non-Western countries. Efforts have been made in Lebanon to better study the characteristics of patients with diabetes mellitus in order to improve glycemic control and prevent late-term complications. AIM: To investigate control and therapeutic management of patients with diabetes mellitus in the current medical practice in Lebanon. METHODS: Wave 6 of the International Diabetes Management Practice Study in Lebanon is an international and multicenter study involving selected countries. RESULTS: Only 1 patient with type 1 diabetes and 595 patients with type 2 diabetes were included in Wave 6. Average age was around 60 years, with a mean body mass index of 30. The mean fasting serum glucose was 159.42 mg/dL, and the mean glycosylated hemoglobin (HbA1c) level was 7.98 with around 30% achieving an HbA1c target of < 7%. More patients were on oral anti-diabetic medications. Screening of diabetic complications has improved over the years. A large percentage is diagnosed with hypertension and dyslipidemia, the majority of whom were treated but only a small percentage were controlled. CONCLUSION: Diabetes, with its associated dyslipidemia and hypertension, is still not very well controlled. Screening for diabetes complications has improved over the years. Patients need to have more proper care, and physicians need to follow diabetes guidelines, and to have a larger number of patients who have appropriate treatment of diabetes, hypertension and lipids.

Treatment registry in focal epilepsy (TRIP): multicenter observational study in Lebanon.

PURPOSE: Treatment of newly diagnosed epilepsy with a single antiepileptic drug (AED) is the favored approach for seizure management. This observational study aimed to assess, under daily practice conditions, remission and retention rates with the first AED prescribed as monotherapy in patients newly or recently diagnosed with focal epilepsy. METHODS: The treatment registry in focal epilepsy (TRIP) study was conducted on 234 Lebanese patients with newly or recently diagnosed focal epilepsy, requiring treatment with an AED. Demographics, baseline focal seizure characteristics and results of the Clinical Global Impression (CGI) scale at the 12-month visit were reported. The primary objective of this study was to assess the percentage of patients who achieved a 6-month terminal seizure remission at the 12-month visit following treatment with a first AED administered as monotherapy. Secondary outcome variables included the calculation of the 6-month terminal seizure remission according to the baseline seizure types and patient retention at the 12 and 18 month visits. In addition, bivariate and multivariate analyses were conducted to identify independent predictors of 6-month terminal seizure remission at the 12-month visit. RESULTS: The mean age of the 234 eligible patients was 31.6 years and the majority were males (62%). At baseline, the most common type of focal seizures was focal seizures with impairment of consciousness (45%), and the most frequent topographical localization was in the temporal lobe (47%). In total, 77.6% of the patients achieved a 6-month terminal seizure remission at the 12-month visit. Patients with an epileptogenic lesion on neuroimaging were significantly less likely to achieve a 6-month remission compared to those with no identifiable pathological substrate. Patients with focal motor seizures without impairment of consciousness at baseline had significantly lower odds of achieving a 6-month terminal seizure remission compared to patients with a combination of seizure types. There was no significant association between age or gender and 6-month terminal seizure remission. The retention rates were 95.7% and 88.5% at months 12 and 18 respectively with the great majority of patients (90.7%) reporting marked improvement on the CGI scale. CONCLUSIONS: A substantial proportion of patients with newly diagnosed epilepsy achieved a 6-month terminal seizure remission following treatment with a first AED administered as monotherapy. Patients with an epileptogenic lesion on neuroimaging and those with focal motor seizures without impairment of consciousness at baseline were significantly less likely to achieve a 6-month terminal seizure remission. This study demonstrated the feasibility of conducting long-term multicenter studies in Lebanon and will hopefully serve as an impetus to conduct randomized studies in the field of epilepsy.