Detalhe da pesquisa
1.
Alternate strategies to obtain mass balance without the use of radiolabeled compounds: application of quantitative fluorine (19F) nuclear magnetic resonance (NMR) spectroscopy in metabolism studies.
Chem Res Toxicol
; 25(3): 572-83, 2012 Mar 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-22292524
2.
Application of quantitative NMR in pharmacological evaluation of biologically generated metabolites: implications in drug discovery.
Drug Metab Dispos
; 39(1): 106-16, 2011 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20952552
3.
Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer.
J Med Chem
; 64(18): 13410-13428, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34499493
4.
Metabolism of vabicaserin in mice, rats, dogs, monkeys, and humans.
Drug Metab Dispos
; 38(12): 2266-77, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20739639
5.
In vitro metabolism, permeability, and efflux of bazedoxifene in humans.
Drug Metab Dispos
; 38(9): 1471-9, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20516255
6.
In vitro metabolism and identification of human enzymes involved in the metabolism of methylnaltrexone.
Drug Metab Dispos
; 38(5): 801-7, 2010 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-20173089
7.
Species differences in the formation of vabicaserin carbamoyl glucuronide.
Drug Metab Dispos
; 38(4): 581-90, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20032194
8.
Characterization of HKI-272 covalent binding to human serum albumin.
Drug Metab Dispos
; 38(7): 1083-93, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20400660
9.
Metabolism of intravenous methylnaltrexone in mice, rats, dogs, and humans.
Drug Metab Dispos
; 38(4): 606-16, 2010 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-20053817
10.
Metabolic disposition of [14C]bazedoxifene in healthy postmenopausal women.
Drug Metab Dispos
; 37(6): 1219-25, 2009 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-19273530
11.
Nuclear magnetic resonance spectroscopy as a quantitative tool to determine the concentrations of biologically produced metabolites: implications in metabolites in safety testing.
Chem Res Toxicol
; 22(2): 299-310, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-18980340
12.
Obtaining exposures of metabolites in preclinical species through plasma pooling and quantitative NMR: addressing metabolites in safety testing (MIST) guidance without using radiolabeled compounds and chemically synthesized metabolite standards.
Chem Res Toxicol
; 22(2): 311-22, 2009 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19067650
13.
Mechanism study of N-dephenylation mediated through a N-para-hydroxy metabolite.
Curr Drug Discov Technol
; 3(2): 101-14, 2006 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-16925518
14.
Reversible covalent binding of neratinib to human serum albumin in vitro.
Drug Metab Lett
; 4(4): 220-7, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20690900
15.
Development of a UGT1A1 reporter gene assay for induction studies: correlation between reporter gene data and regulation of UGT1A1 in human hepatocytes.
Drug Metab Lett
; 4(1): 31-8, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-20201778
16.
Metabolism, excretion, and pharmacokinetics of [14C]tigecycline, a first-in-class glycylcycline antibiotic, after intravenous infusion to healthy male subjects.
Drug Metab Dispos
; 35(9): 1543-53, 2007 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-17537869
17.
Application of pharmacogenomics in drug discovery and development: correlations between transcriptional modulation and preclinical safety observations.
Drug Metab Lett
; 1(1): 41-8, 2007 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19356017
18.
A novel approach for predicting acyl glucuronide reactivity via Schiff base formation: development of rapidly formed peptide adducts for LC/MS/MS measurements.
Chem Res Toxicol
; 17(9): 1206-16, 2004 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-15377154
19.
Lipopolysaccharide-mediated modulation of cytochromes P450 in Stat1 null mice.
Drug Metab Dispos
; 31(4): 392-7, 2003 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-12642464
20.
Quantitation of cytochrome P450 mRNA levels in human skin.
Anal Biochem
; 316(1): 103-10, 2003 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-12694732