Detalhe da pesquisa
1.
Safety, tolerability, and pharmacokinetics of Aurora kinase B inhibitor AZD2811: a phase 1 dose-finding study in patients with advanced solid tumours.
Br J Cancer
; 128(10): 1906-1915, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36871042
2.
Clinical evaluation of the potential drug-drug interactions of savolitinib: Interaction with rifampicin, itraconazole, famotidine or midazolam.
Br J Clin Pharmacol
; 88(2): 655-668, 2022 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-34322894
3.
Concentration-QT modelling in early clinical oncology settings: Simulation evaluation of performance.
Br J Clin Pharmacol
; 88(3): 1010-1019, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34416045
4.
Normal fat mass cannot be reliably estimated in typical pharmacokinetic studies.
Eur J Clin Pharmacol
; 77(5): 727-733, 2021 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-33205282
5.
Importance of Prospective Studies in Pregnant and Breastfeeding Women Living With Human Immunodeficiency Virus.
Clin Infect Dis
; 69(7): 1254-1258, 2019 09 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30783649
6.
Evaluating darunavir/ritonavir dosing regimens for HIV-positive pregnant women using semi-mechanistic pharmacokinetic modelling.
J Antimicrob Chemother
; 74(5): 1348-1356, 2019 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30715324
7.
Lowered Rilpivirine Exposure During the Third Trimester of Pregnancy in Human Immunodeficiency Virus Type 1-Infected Women.
Clin Infect Dis
; 65(8): 1335-1341, 2017 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28595298
8.
Placental transfer of the HIV integrase inhibitor dolutegravir in an ex vivo human cotyledon perfusion model.
J Antimicrob Chemother
; 71(2): 480-3, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26538508
9.
Maraviroc Pharmacokinetics in HIV-1-Infected Pregnant Women.
Clin Infect Dis
; 61(10): 1582-9, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26202768
10.
Declining efficacy in controlled trials of antidepressants: effects of placebo dropout.
Int J Neuropsychopharmacol
; 17(8): 1343-52, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24621827
11.
Free dug concentrations in pregnancy: Bound to measure unbound?
Br J Clin Pharmacol
; 83(12): 2595-2598, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28983934
12.
Parent and Metabolite Concentration-QT Modeling to Evaluate QT-Interval Prolongation at Savolitinib Therapeutic Doses.
AAPS J
; 23(3): 46, 2021 03 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-33733338
13.
Physiologically Based Pharmacokinetic Modeling for Selumetinib to Evaluate Drug-Drug Interactions and Pediatric Dose Regimens.
J Clin Pharmacol
; 61(11): 1493-1504, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34196005
14.
Population pharmacokinetics and exposure-response of selumetinib and its N-desmethyl metabolite in pediatric patients with neurofibromatosis type 1 and inoperable plexiform neurofibromas.
Cancer Chemother Pharmacol
; 88(2): 189-202, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-33903938
15.
A phase 1/2 study of the combination of acalabrutinib and vistusertib in patients with relapsed/refractory B-cell malignancies.
Leuk Lymphoma
; 62(11): 2625-2636, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34269152
16.
Assessment of Maternal and Fetal Dolutegravir Exposure by Integrating Ex Vivo Placental Perfusion Data and Physiologically-Based Pharmacokinetic Modeling.
Clin Pharmacol Ther
; 107(6): 1352-1361, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31868223
17.
Development and validation of an UPLC-MS/MS bioanalytical method for simultaneous quantification of the antiretroviral drugs dolutegravir, elvitegravir, raltegravir, nevirapine and etravirine in human plasma.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1105: 76-84, 2019 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30572204
18.
Efavirenz pharmacokinetics during pregnancy and infant washout.
Antivir Ther
; 24(2): 95-103, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530925
19.
Pharmacokinetics of HIV-Integrase Inhibitors During Pregnancy: Mechanisms, Clinical Implications and Knowledge Gaps.
Clin Pharmacokinet
; 58(3): 309-323, 2019 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29915921
20.
Prediction of Fetal Darunavir Exposure by Integrating Human Ex-Vivo Placental Transfer and Physiologically Based Pharmacokinetic Modeling.
Clin Pharmacokinet
; 57(6): 705-716, 2018 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28744795