Detalhe da pesquisa
1.
The sphingosine-1-phosphate receptor 1 modulator ponesimod repairs cuprizone-induced demyelination and induces oligodendrocyte differentiation.
FASEB J
; 38(2): e23413, 2024 01 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38243760
2.
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-ß pathology.
Cell Mol Life Sci
; 80(7): 178, 2023 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37306762
3.
The Molecular Biology of Phosphodiesterase 4 Enzymes as Pharmacological Targets: An Interplay of Isoforms, Conformational States, and Inhibitors.
Pharmacol Rev
; 73(3): 1016-1049, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-34233947
4.
From methylation to myelination: epigenomic and transcriptomic profiling of chronic inactive demyelinated multiple sclerosis lesions.
Acta Neuropathol
; 146(2): 283-299, 2023 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-37286732
5.
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.
Brain Behav Immun
; 109: 1-22, 2023 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36584795
6.
Soluble guanylyl cyclase: A novel target for the treatment of vascular cognitive impairment?
Pharmacol Res
; 197: 106970, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37884069
7.
Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination.
Proc Natl Acad Sci U S A
; 117(9): 5028-5038, 2020 03 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-32071226
8.
Unleashing Spinal Cord Repair: The Role of cAMP-Specific PDE Inhibition in Attenuating Neuroinflammation and Boosting Regeneration after Traumatic Spinal Cord Injury.
Int J Mol Sci
; 24(9)2023 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37175842
9.
DNA methylation regulates the expression of the negative transcriptional regulators ID2 and ID4 during OPC differentiation.
Cell Mol Life Sci
; 78(19-20): 6631-6644, 2021 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-34482420
10.
Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders.
Cell Mol Life Sci
; 78(10): 4615-4637, 2021 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-33751149
11.
Positive effects of roflumilast on behavior, neuroinflammation, and white matter injury in mice with global cerebral ischemia.
Behav Pharmacol
; 32(6): 459-471, 2021 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34320520
12.
24(S)-Saringosterol Prevents Cognitive Decline in a Mouse Model for Alzheimer's Disease.
Mar Drugs
; 19(4)2021 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-33801706
13.
Sphingosine-1-Phosphate Receptor Modulators and Oligodendroglial Cells: Beyond Immunomodulation.
Int J Mol Sci
; 21(20)2020 Oct 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33066042
14.
Beta-amyloid interacts with and activates the long-form phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability.
FEBS Lett
; 2024 May 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-38724485
15.
Amelioration of functional and histopathological consequences after spinal cord injury through phosphodiesterase 4D (PDE4D) inhibition.
Neurotherapeutics
; : e00372, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38760316
16.
Exogenous Oxytocin Administration Restores Memory in Female APP/PS1 Mice.
J Alzheimers Dis
; 96(3): 1207-1219, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37927260
17.
Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model.
Eur J Pharm Sci
; 185: 106441, 2023 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37004962
18.
Cerebral microvascular endothelial cell-derived extracellular vesicles regulate blood - brain barrier function.
Fluids Barriers CNS
; 20(1): 95, 2023 Dec 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-38114994
19.
The sGC stimulator BAY-747 and activator runcaciguat can enhance memory in vivo via differential hippocampal plasticity mechanisms.
Sci Rep
; 12(1): 3589, 2022 03 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35246566
20.
Neuroinflammation in Ischemic Stroke: Inhibition of cAMP-Specific Phosphodiesterases (PDEs) to the Rescue.
Biomedicines
; 9(7)2021 Jun 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-34206420