Detalhe da pesquisa
1.
Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects.
J Chem Inf Model
; 60(11): 5457-5474, 2020 11 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-32813975
2.
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.
Nat Chem Biol
; 11(12): 973-980, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26502155
3.
Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore.
Bioorg Med Chem Lett
; 26(5): 1443-51, 2016 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26852363
4.
The discovery and optimization of hexahydro-2H-pyrano[3,2-c]quinolines (HHPQs) as potent and selective inhibitors of the mitotic kinesin-5.
Bioorg Med Chem Lett
; 20(5): 1491-5, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149654
5.
2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19.
ACS Med Chem Lett
; 7(6): 573-8, 2016 Jun 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27326329
6.
Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening.
J Med Chem
; 59(20): 9337-9349, 2016 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-27490956
7.
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19.
J Med Chem
; 59(3): 1078-101, 2016 Feb 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-26796641
8.
Assessing the mechanism and therapeutic potential of modulators of the human Mediator complex-associated protein kinases.
Elife
; 52016 12 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27935476
9.
Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.
J Med Chem
; 58(4): 1717-35, 2015 Feb 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-25680029
10.
Development of Polymer-Supported Benzotriazole as a Novel Traceless Linker for Solid-Phase Organic Synthesis(1).
J Org Chem
; 64(13): 4972-4975, 1999 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-11674585
11.
Dual 5-HT1A agonists and 5-HT re-uptake inhibitors by combination of indole-butyl-amine and chromenonyl-piperazine structural elements in a single molecular entity.
Bioorg Med Chem
; 12(18): 4843-52, 2004 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-15336263