Detalhe da pesquisa
1.
Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis.
J Biol Chem
; 296: 100263, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33837744
2.
Mammalian-like type II glutaminyl cyclases in Porphyromonas gingivalis and other oral pathogenic bacteria as targets for treatment of periodontitis.
J Biol Chem
; 2021 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-33402424
3.
A glutaminyl cyclase-catalyzed α-synuclein modification identified in human synucleinopathies.
Acta Neuropathol
; 142(3): 399-421, 2021 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34309760
4.
Structure and Dynamics of Meprin ß in Complex with a Hydroxamate-Based Inhibitor.
Int J Mol Sci
; 22(11)2021 May 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-34073350
5.
Combination of the Glutaminyl Cyclase Inhibitor PQ912 (Varoglutamstat) and the Murine Monoclonal Antibody PBD-C06 (m6) Shows Additive Effects on Brain Aß Pathology in Transgenic Mice.
Int J Mol Sci
; 22(21)2021 Oct 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34769222
6.
Hydrazides Are Potent Transition-State Analogues for Glutaminyl Cyclase Implicated in the Pathogenesis of Alzheimer's Disease.
Biochemistry
; 59(28): 2585-2591, 2020 07 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32551535
7.
Amyloid-Beta Peptides Trigger Aggregation of Alpha-Synuclein In Vitro.
Molecules
; 25(3)2020 Jan 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32013170
8.
Posttranslational modification impact on the mechanism by which amyloid-ß induces synaptic dysfunction.
EMBO Rep
; 18(6): 962-981, 2017 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-28420656
9.
Automated extraction of quality indicators for treatment of children with complex developmental disorders: A feasibility study using the example of attention-deficit/hyperactivity disorder.
Int J Qual Health Care
; 31(7): 563-567, 2019 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30295824
10.
Structural and functional analyses of pyroglutamate-amyloid-ß-specific antibodies as a basis for Alzheimer immunotherapy.
J Biol Chem
; 292(30): 12713-12724, 2017 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-28623233
11.
Continuous assays for meprin alpha and beta using prolyl tripeptidyl aminopeptidase (PtP) from Porphyromonas gingivalis.
Anal Biochem
; 559: 11-16, 2018 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30098994
12.
Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-ß.
Nature
; 485(7400): 651-5, 2012 May 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-22660329
13.
Passive Aß Immunotherapy: Current Achievements and Future Perspectives.
Molecules
; 23(5)2018 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-29751505
14.
Glutaminyl Cyclase Inhibitor PQ912 Improves Cognition in Mouse Models of Alzheimer's Disease-Studies on Relation to Effective Target Occupancy.
J Pharmacol Exp Ther
; 362(1): 119-130, 2017 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-28446518
15.
Purification of recombinant Aß(1-42) and pGlu-Aß(3-42) using preparative SDS-PAGE.
Electrophoresis
; 38(16): 2042-2049, 2017 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-28510356
16.
First insight into structure-activity relationships of selective meprin ß inhibitors.
Bioorg Med Chem Lett
; 27(11): 2428-2431, 2017 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28408220
17.
Identification of thyrotropin-releasing hormone as hippocampal glutaminyl cyclase substrate in neurons and reactive astrocytes.
Biochim Biophys Acta
; 1852(1): 146-55, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25446989
18.
IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes.
Biol Chem
; 397(1): 45-55, 2016 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-26351917
19.
Isoglutaminyl cyclase contributes to CCL2-driven neuroinflammation in Alzheimer's disease.
Acta Neuropathol
; 129(4): 565-83, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25666182
20.
Phosphate ions and glutaminyl cyclases catalyze the cyclization of glutaminyl residues by facilitating synchronized proton transfers.
Bioorg Chem
; 60: 98-101, 2015 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-25981125