Detalhe da pesquisa
1.
The Dark Side of Cell Signaling: Positive Roles for Negative Regulators.
Cell
; 164(6): 1172-1184, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26967284
2.
Design of protein-binding proteins from the target structure alone.
Nature
; 605(7910): 551-560, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35332283
3.
Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature
; 600(7887): 153-157, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34819673
4.
Structural basis for ligand reception by anaplastic lymphoma kinase.
Nature
; 600(7887): 148-152, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34819665
5.
Integrated mutational landscape analysis of poorly differentiated high-grade neuroendocrine carcinoma of the uterine cervix.
Proc Natl Acad Sci U S A
; 121(17): e2321898121, 2024 Apr 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-38625939
6.
Heparin is essential for optimal cell signaling by FGF21 and for regulation of ßKlotho cellular stability.
Proc Natl Acad Sci U S A
; 120(7): e2219128120, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36745784
7.
Cryo-EM analyses of KIT and oncogenic mutants reveal structural oncogenic plasticity and a target for therapeutic intervention.
Proc Natl Acad Sci U S A
; 120(13): e2300054120, 2023 03 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36943885
8.
Cell signaling by receptor tyrosine kinases.
Cell
; 141(7): 1117-34, 2010 Jun 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-20602996
9.
Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis.
Proc Natl Acad Sci U S A
; 119(48): e2208947119, 2022 11 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36417441
10.
A hypothalamic pathway for Augmentor α-controlled body weight regulation.
Proc Natl Acad Sci U S A
; 119(16): e2200476119, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35412887
11.
The selectivity of receptor tyrosine kinase signaling is controlled by a secondary SH2 domain binding site.
Cell
; 138(3): 514-24, 2009 Aug 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-19665973
12.
Structures of ß-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.
Nature
; 553(7689): 501-505, 2018 01 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29342135
13.
Integrated mutational landscape analysis of uterine leiomyosarcomas.
Proc Natl Acad Sci U S A
; 118(15)2021 04 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-33876771
14.
Uterine leiomyosarcomas harboring MAP2K4 gene amplification are sensitive in vivo to PLX8725, a novel MAP2K4 inhibitor.
Gynecol Oncol
; 172: 65-71, 2023 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36958197
15.
The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Mol Cell
; 57(1): 191-201, 2015 Jan 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-25544564
16.
FGF23 contains two distinct high-affinity binding sites enabling bivalent interactions with α-Klotho.
Proc Natl Acad Sci U S A
; 117(50): 31800-31807, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33257569
17.
Scaffold association factor B (SAFB) is required for expression of prenyltransferases and RAS membrane association.
Proc Natl Acad Sci U S A
; 117(50): 31914-31922, 2020 12 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33257571
18.
Structures of ligand-occupied ß-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity.
Proc Natl Acad Sci U S A
; 116(16): 7819-7824, 2019 04 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-30944224
19.
Mutational landscape of primary, metastatic, and recurrent ovarian cancer reveals c-MYC gains as potential target for BET inhibitors.
Proc Natl Acad Sci U S A
; 116(2): 619-624, 2019 01 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30584090
20.
Whole-exome sequencing of cervical carcinomas identifies activating ERBB2 and PIK3CA mutations as targets for combination therapy.
Proc Natl Acad Sci U S A
; 116(45): 22730-22736, 2019 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31624127