Detalhe da pesquisa
1.
High Prevalence of Plasmodium falciparum K13 Mutations in Rwanda Is Associated With Slow Parasite Clearance After Treatment With Artemether-Lumefantrine.
J Infect Dis
; 225(8): 1411-1414, 2022 04 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-34216470
2.
Efficacy of Cipargamin (KAE609) in a Randomized, Phase II Dose-Escalation Study in Adults in Sub-Saharan Africa With Uncomplicated Plasmodium falciparum Malaria.
Clin Infect Dis
; 74(10): 1831-1839, 2022 05 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-34410358
3.
Hepatic safety and tolerability of cipargamin (KAE609), in adult patients with Plasmodium falciparum malaria: a randomized, phase II, controlled, dose-escalation trial in sub-Saharan Africa.
Malar J
; 20(1): 478, 2021 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34930267
4.
Natural products as probes in pharmaceutical research.
J Ind Microbiol Biotechnol
; 43(2-3): 249-60, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26438431
5.
Gift from Nature: Cyclomarinâ A Kills Mycobacteria and Malaria Parasites by Distinct Modes of Action.
Chembiochem
; 16(17): 2433-6, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26472355
6.
Luteipulveratus halotolerans sp. nov., an actinobacterium (Dermacoccaceae) from forest soil.
Int J Syst Evol Microbiol
; 65(11): 4113-4120, 2015 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-26303235
7.
Nannocystinâ A: an Elongation Factor 1 Inhibitor from Myxobacteria with Differential Anti-Cancer Properties.
Angew Chem Int Ed Engl
; 54(35): 10149-54, 2015 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-26179970
8.
A G358S mutation in the Plasmodium falciparum Na+ pump PfATP4 confers clinically-relevant resistance to cipargamin.
Nat Commun
; 13(1): 5746, 2022 09 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-36180431
9.
The early preclinical and clinical development of cipargamin (KAE609), a novel antimalarial compound.
Travel Med Infect Dis
; 36: 101765, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32561392
10.
Ribosomally synthesized thiopeptide antibiotics targeting elongation factor Tu.
J Am Chem Soc
; 131(16): 5946-55, 2009 Apr 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-19338336
11.
Triclabendazole in the treatment of human fascioliasis: a review.
Trans R Soc Trop Med Hyg
; 113(12): 797-804, 2019 12 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31638149
12.
Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis.
J Antimicrob Chemother
; 62(4): 713-9, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18587134
13.
Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.
Cell Host Microbe
; 22(1): 25-37.e6, 2017 Jul 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28704649
14.
The natural product cyclomarin kills Mycobacterium tuberculosis by targeting the ClpC1 subunit of the caseinolytic protease.
Angew Chem Int Ed Engl
; 50(26): 5889-91, 2011 Jun 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21563281
15.
The novolactone natural product disrupts the allosteric regulation of Hsp70.
Chem Biol
; 22(1): 87-97, 2015 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25544045
16.
AcFKH1, a novel member of the forkhead family, associates with the RFX transcription factor CPCR1 in the cephalosporin C-producing fungus Acremonium chrysogenum.
Gene
; 342(2): 269-81, 2004 Nov 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-15527986
17.
High-resolution chemical dissection of a model eukaryote reveals targets, pathways and gene functions.
Microbiol Res
; 169(2-3): 107-20, 2014.
Artigo
em Inglês
| MEDLINE | ID: mdl-24360837
18.
Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin.
Cell Host Microbe
; 11(6): 654-63, 2012 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-22704625
19.
Natural products as catalysts for innovation: a pharmaceutical industry perspective.
Curr Opin Chem Biol
; 15(4): 497-504, 2011 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-21684800
20.
Spiroindolones, a potent compound class for the treatment of malaria.
Science
; 329(5996): 1175-80, 2010 Sep 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-20813948