1.
Immunobiology
; 166(4-5): 335-44, 1984 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6480029
RESUMO
C4 gene and haplotype frequencies were calculated from phenotype data of 380 unrelated Caucasian patients with insulin dependent (type 1) diabetes mellitus and were compared with analogous frequencies of 382 unrelated healthy Caucasian individuals. In diabetics, a significantly increased frequency of the rare allele C4B 3 (p less than 10(-7] and of the silent alleles C4A Q0 (p less than 10(-7] and B Q0 (p less than 0.002) was observed. Accordingly, insulin dependent diabetes is associated with partial C4 deficiency, which may contribute to the pathogenesis of the disease.
Assuntos
Complemento C4/genética , Diabetes Mellitus Tipo 1/imunologia , Alelos , Complemento C4/deficiência , Diabetes Mellitus Tipo 1/genética , Frequência do Gene , Humanos , Polimorfismo Genético
2.
Lancet
; 1(8262): 41, 1982 Jan 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6119428