Detalhe da pesquisa
1.
Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism.
Mol Cell
; 84(10): 1948-1963.e11, 2024 May 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38759627
2.
Inhibition of CPAP-tubulin interaction prevents proliferation of centrosome-amplified cancer cells.
EMBO J
; 38(2)2019 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30530478
3.
High-Content Screening Identifies Cyclosporin A as a Novel ABCA3-Specific Molecular Corrector.
Am J Respir Cell Mol Biol
; 66(4): 382-390, 2022 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34936540
4.
Mitochondrial Alkbh1 localizes to mtRNA granules and its knockdown induces the mitochondrial UPR in humans and C. elegans.
J Cell Sci
; 132(19)2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31434717
5.
A high-content screen for small-molecule regulators of epithelial cell-adhesion molecule (EpCAM) cleavage yields a robust inhibitor.
J Biol Chem
; 293(23): 8994-9005, 2018 06 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-29700109
6.
Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity.
J Biol Chem
; 293(34): 13191-13203, 2018 08 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-29950522
7.
Role of the ubiquitin-like protein Urm1 as a noncanonical lysine-directed protein modifier.
Proc Natl Acad Sci U S A
; 108(5): 1763-70, 2011 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21209336
8.
CellDeathPred: a deep learning framework for ferroptosis and apoptosis prediction based on cell painting.
Cell Death Discov
; 9(1): 277, 2023 Jul 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37524741
9.
Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis.
Nat Commun
; 14(1): 6908, 2023 10 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-37903763
10.
Methods to Detect Small Molecule Inhibition of RING E3 Ligase Activity.
Curr Protoc
; 2(4): e414, 2022 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-35435333
11.
Machine Learning Classifies Ferroptosis and Apoptosis Cell Death Modalities with TfR1 Immunostaining.
ACS Chem Biol
; 17(3): 654-660, 2022 03 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-35230809
12.
Unleashing high content screening in hit detection - Benchmarking AI workflows including novelty detection.
Comput Struct Biotechnol J
; 20: 5453-5465, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36212538
13.
Small molecule mediated inhibition of protein cargo recognition by peroxisomal transport receptor PEX5 is toxic to Trypanosoma.
Sci Rep
; 12(1): 14705, 2022 08 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-36038611
14.
Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
Eur J Med Chem
; 243: 114778, 2022 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36194937
15.
Acriflavine, a clinically approved drug, inhibits SARS-CoV-2 and other betacoronaviruses.
Cell Chem Biol
; 29(5): 774-784.e8, 2022 05 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-35021060
16.
Studying OTUD6B-OTUB1 Protein-Protein Interaction by Low-Throughput GFP-Trap Assays and High-Throughput AlphaScreen Assays.
Methods Mol Biol
; 2261: 381-394, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-33421002
17.
Inhalational Anesthetics Do Not Deteriorate Amyloid-ß-Derived Pathophysiology in Alzheimer's Disease: Investigations on the Molecular, Neuronal, and Behavioral Level.
J Alzheimers Dis
; 84(3): 1193-1218, 2021.
Artigo
em Inglês
| MEDLINE | ID: mdl-34657881
18.
A drug screen with approved compounds identifies amlexanox as a novel Wnt/ß-catenin activator inducing lung epithelial organoid formation.
Br J Pharmacol
; 178(19): 4026-4041, 2021 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34089180
19.
Retinoic acid signaling is critical during the totipotency window in early mammalian development.
Nat Struct Mol Biol
; 28(6): 521-532, 2021 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34045724
20.
Activation of HERV-K(HML-2) disrupts cortical patterning and neuronal differentiation by increasing NTRK3.
Cell Stem Cell
; 28(9): 1566-1581.e8, 2021 09 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-33951478