Detalhe da pesquisa
1.
Targeting the untargetable: RB1-deficient tumours are vulnerable to Skp2 ubiquitin ligase inhibition.
Br J Cancer
; 127(6): 969-975, 2022 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35752713
2.
Lysosome Membrane Permeabilization and Disruption of the Molecular Target of Rapamycin (mTOR)-Lysosome Interaction Are Associated with the Inhibition of Lung Cancer Cell Proliferation by a Chloroquinoline Analog.
Mol Pharmacol
; 95(1): 127-138, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30409790
3.
SKP2 Knockout in Rb1/p53-Deficient Mouse Models of Osteosarcoma Induces Immune Infiltration and Drives a Transcriptional Program with a Favorable Prognosis.
Mol Cancer Ther
; 23(2): 223-234, 2024 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37871911
4.
Targeted inhibition of SCFSKP2 confers anti-tumor activities resulting in a survival benefit in osteosarcoma.
Oncogene
; 43(13): 962-975, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38355807
5.
Paracrine stimulation of endothelial cell motility and angiogenesis by platelet-derived deoxyribose-1-phosphate.
Arterioscler Thromb Vasc Biol
; 30(12): 2631-8, 2010 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-20884872
6.
The interaction of SKP2 with p27 enhances the progression and stemness of osteosarcoma.
Ann N Y Acad Sci
; 1490(1): 90-104, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33594717
7.
Antivascular actions of microtubule-binding drugs.
Clin Cancer Res
; 15(8): 2594-601, 2009 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19351751
8.
Targeted Inhibition of the E3 Ligase SCFSkp2/Cks1 Has Antitumor Activity in RB1-Deficient Human and Mouse Small-Cell Lung Cancer.
Cancer Res
; 80(11): 2355-2367, 2020 06 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32265224
9.
Skp2 depletion reduces tumor-initiating properties and promotes apoptosis in synovial sarcoma.
Transl Oncol
; 13(10): 100809, 2020 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-32623326
10.
Mechanisms by which tumor cells and monocytes expressing the angiogenic factor thymidine phosphorylase mediate human endothelial cell migration.
Cancer Res
; 63(2): 527-33, 2003 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-12543812
11.
Gene expression profiling-based prediction of response of colon carcinoma cells to 5-fluorouracil and camptothecin.
Cancer Res
; 63(24): 8791-812, 2003 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-14695196
12.
The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells.
Oncogene
; 21(55): 8477-85, 2002 Dec 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-12466967
13.
Inhibition of endothelial cell function in vitro and angiogenesis in vivo by docetaxel (Taxotere): association with impaired repositioning of the microtubule organizing center.
Mol Cancer Ther
; 1(13): 1191-200, 2002 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-12479700
14.
Discovery of autophagy inhibitors with antiproliferative activity in lung and pancreatic cancer cells.
ACS Med Chem Lett
; 6(2): 134-9, 2015 Feb 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-25699157
15.
RICTOR Amplification Defines a Novel Subset of Patients with Lung Cancer Who May Benefit from Treatment with mTORC1/2 Inhibitors.
Cancer Discov
; 5(12): 1262-70, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26370156
16.
The autophagy inhibitor chloroquine overcomes the innate resistance of wild-type EGFR non-small-cell lung cancer cells to erlotinib.
J Thorac Oncol
; 8(6): 693-702, 2013 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-23575415
17.
Antiangiogenic and antitumor activity of 6-(2-aminoethyl)amino-5-chlorouracil, a novel small-molecule inhibitor of thymidine phosphorylase, in combination with the vascular endothelial growth factor-trap.
Clin Cancer Res
; 15(16): 5136-44, 2009 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-19671868
18.
Interference with endothelial cell function by JG-03-14, an agent that binds to the colchicine site on microtubules.
Biochem Pharmacol
; 78(9): 1167-77, 2009 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19576183
19.
The microtubule binding drug laulimalide inhibits vascular endothelial growth factor-induced human endothelial cell migration and is synergistic when combined with docetaxel (taxotere).
Mol Pharmacol
; 69(4): 1207-15, 2006 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-16415178
20.
Taxotere-induced inhibition of human endothelial cell migration is a result of heat shock protein 90 degradation.
Cancer Res
; 66(16): 8192-9, 2006 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-16912198