RESUMO
Antecedentes: La erupción debida a la fijación de un fármaco (EFF) es un trastorno cutáneo frecuente, que se desarrolla a las pocas horas de ingerir el fármaco agresor y recurre en la misma zona si hay una exposición posterior al mismo fármaco. Los antiinflamatorios no esteroideos (AINE) son fármacos que producen agresiones de este tipo habitualmente. Métodos: Una niña de catorce años se presentó en consulta inicialmente habiendo experimentado durante un año recurrencias de una placa rojiza-castaña alrededor de la areola derecha. La lesión se hizo prurítica, surgía durante las menstruaciones y desaparecía durante el resto del ciclo menstrual, con la excepción de una hiperpigmentación residual, que persistía. La paciente consumía naproxeno durante la menstruación para aliviar la dismenorrea. Resultados: Se hizo una biopsia de piel que demostró la presencia de ampollas locales y queratinocitos necróticos dispersos en la epidermis, degeneración hidrópica de la capa de células basales, incontinencia pigmentaria e infiltrado perivascular compuesto de linfocitos y eosinófilos. Estos cambios confirmaron el diagnóstico de erupción por fijación de fármaco. Conclusiones: La erupción debida a fijación de fármacos antiinflamatorios no esteroideos es frecuente. Sin embargo, la EFF debida a naproxeno, uno de estos AINE, se ha descrito muy pocas veces. Describimos un caso poco habitual de EFF, con recurrencia en todas las menstruaciones (AU)
Assuntos
Adolescente , Feminino , Humanos , Toxidermias/patologia , Doenças Mamárias/induzido quimicamente , Naproxeno/efeitos adversos , Anti-Inflamatórios não Esteroides/efeitos adversosRESUMO
Eight of the more than 80 known herpesviruses are human pathogens. Human herpes simplex virus (HSV) is a contagious infection with a large reservoir in the general population. It has a potential for significant complications in the immunocompromised host. In addition, psychological distress caused by the negative stigma associated with genital herpes and visible facial lesions in those experiencing frequent outbreaks renders it a challenging clinical dilemma. This article reviews the epidemiology, pathogenesis, and diagnostic features of HSV infections, providing the clinician with an up-to-date understanding of the available management strategies for mucocutaneous HSV-induced disease.
Assuntos
Infecções Sexualmente Transmissíveis/epidemiologia , Infecções Sexualmente Transmissíveis/fisiopatologia , Infecções Sexualmente Transmissíveis/virologia , Herpes Simples/epidemiologia , Herpes Simples/fisiopatologia , Herpes Simples/imunologia , Herpes Simples/parasitologia , Herpes Simples/virologia , Eczema/epidemiologia , Eczema/fisiopatologia , Eczema/virologia , Herpes Genital/epidemiologia , Herpes Genital/virologia , Herpes Labial/epidemiologia , Herpes Labial/virologiaRESUMO
The concept of verrucous carcinoma as a clinicopathologic variant of squamous cell carcinoma is worthy of recognition. It is known by a confusing array of names, such as Ackerman's tumor, Buschke-Loewenstein tumor, florid oral papillomatosis, epithelioma cuniculatum, carcinoma cuniculatum, and cutis papillomatosis carcinoides of Gottron. Its apparent clinical benignity may lead to lengthy periods of misdiagnosis, during which it is likely not to spread to distant lymph nodes, but rather to destroy a nose, mandible, or penis as it slowly but relentlessly extends into underlying tissue. Morphologically warty or verrucous, its relatively bland histologic features are often more suggestive of a verruca vulgaris or pseudoepitheliomatous hyperplasia than of squamous cell carcinoma to those unfamiliar with the diagnosis. Alternatively, when it extends into underlying tissues, it may be mistaken histologically for a benign adnexal tumor or even an epidermoid cyst. Therapy may also be challenging because recurrences are common and concerns about potential anaplastic transformation after radiotherapy are often expressed.