Pesquisa | Biblioteca Virtual em Saúde

1.

Structural basis for the action of the drug trametinib at KSR-bound MEK.

Khan, Zaigham M; Real, Alexander M; Marsiglia, William M; Chow, Arthur; Duffy, Mary E; Yerabolu, Jayasudhan R; Scopton, Alex P; Dar, Arvin C.

Nature ; 588(7838): 509-514, 2020 12.

Artigo em Inglês | MEDLINE | ID: mdl-32927473

2.

Small molecule stabilization of the KSR inactive state antagonizes oncogenic Ras signalling.

Dhawan, Neil S; Scopton, Alex P; Dar, Arvin C.

Nature ; 537(7618): 112-116, 2016 09 01.

Artigo em Inglês | MEDLINE | ID: mdl-27556948

3.

Type II Binders Targeting the "GLR-Out" Conformation of the Pseudokinase STRADα.

Smith, Ryan H B; Khan, Zaigham M; Ung, Peter Man-Un; Scopton, Alex P; Silber, Lisa; Mack, Seshat M; Real, Alexander M; Schlessinger, Avner; Dar, Arvin C.

Biochemistry ; 60(4): 289-302, 2021 02 02.

Artigo em Inglês | MEDLINE | ID: mdl-33440120

4.

A whole-animal platform to advance a clinical kinase inhibitor into new disease space.

Sonoshita, Masahiro; Scopton, Alex P; Ung, Peter M U; Murray, Matthew A; Silber, Lisa; Maldonado, Andres Y; Real, Alexander; Schlessinger, Avner; Cagan, Ross L; Dar, Arvin C.

Nat Chem Biol ; 14(3): 291-298, 2018 03.

Artigo em Inglês | MEDLINE | ID: mdl-29355849

5.

Integrated computational and Drosophila cancer model platform captures previously unappreciated chemicals perturbing a kinase network.

Ung, Peter M U; Sonoshita, Masahiro; Scopton, Alex P; Dar, Arvin C; Cagan, Ross L; Schlessinger, Avner.

PLoS Comput Biol ; 15(4): e1006878, 2019 04.

Artigo em Inglês | MEDLINE | ID: mdl-31026276

6.

Identification of novel functionally selective κ-opioid receptor scaffolds.

White, Kate L; Scopton, Alex P; Rives, Marie-Laure; Bikbulatov, Ruslan V; Polepally, Prabhakar R; Brown, Peter J; Kenakin, Terrance; Javitch, Jonathan A; Zjawiony, Jordan K; Roth, Bryan L.

Mol Pharmacol ; 85(1): 83-90, 2014 Jan.

Artigo em Inglês | MEDLINE | ID: mdl-24113749

7.

WNTinib is a multi-kinase inhibitor with specificity against ß-catenin mutant hepatocellular carcinoma.

Rialdi, Alex; Duffy, Mary; Scopton, Alex P; Fonseca, Frank; Zhao, Julia Nanyi; Schwarz, Megan; Molina-Sanchez, Pedro; Mzoughi, Slim; Arceci, Elisa; Abril-Fornaguera, Jordi; Meadows, Austin; Ruiz de Galarreta, Marina; Torre, Denis; Reyes, Kyna; Lim, Yan Ting; Rosemann, Felix; Khan, Zaigham M; Mohammed, Kevin; Wang, Xuedi; Yu, Xufen; Lakshmanan, Manikandan; Rajarethinam, Ravisankar; Tan, Soo Yong; Jin, Jian; Villanueva, Augusto; Michailidis, Eleftherios; De Jong, Ype P; Rice, Charles M; Marazzi, Ivan; Hasson, Dan; Llovet, Josep M; Sobota, Radoslaw M; Lujambio, Amaia; Guccione, Ernesto; Dar, Arvin C.

Nat Cancer ; 4(8): 1157-1175, 2023 08.

Artigo em Inglês | MEDLINE | ID: mdl-37537299

8.

Synthesis of azacridone A.

Scopton, Alex; Kelly, T Ross.

Org Lett ; 6(21): 3869-71, 2004 Oct 14.

Artigo em Inglês | MEDLINE | ID: mdl-15469370

9.

Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors.

Yu, Wenyu; Chory, Emma J; Wernimont, Amy K; Tempel, Wolfram; Scopton, Alex; Federation, Alexander; Marineau, Jason J; Qi, Jun; Barsyte-Lovejoy, Dalia; Yi, Joanna; Marcellus, Richard; Iacob, Roxana E; Engen, John R; Griffin, Carly; Aman, Ahmed; Wienholds, Erno; Li, Fengling; Pineda, Javier; Estiu, Guillermina; Shatseva, Tatiana; Hajian, Taraneh; Al-Awar, Rima; Dick, John E; Vedadi, Masoud; Brown, Peter J; Arrowsmith, Cheryl H; Bradner, James E; Schapira, Matthieu.

Nat Commun ; 3: 1288, 2012.

Artigo em Inglês | MEDLINE | ID: mdl-23250418

10.

Enantioselective pathway for the synthesis of laurenditerpenol.

Mukherjee, Santanu; Scopton, Alex P; Corey, E J.

Org Lett ; 12(8): 1836-8, 2010 Apr 16.

Artigo em Inglês | MEDLINE | ID: mdl-20337419

11.

Synthesis of HKI 0231B.

Scopton, Alex; Kelly, T Ross.

J Org Chem ; 70(24): 10004-12, 2005 Nov 25.

Artigo em Inglês | MEDLINE | ID: mdl-16292834

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