Detalhe da pesquisa
1.
Lucanthone, a Potential PPT1 Inhibitor, Perturbs Stemness, Reduces Tumor Microtube Formation, and Slows the Growth of Temozolomide-Resistant Gliomas In Vivo.
J Pharmacol Exp Ther
; 389(1): 51-60, 2024 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38296645
2.
Discovery and molecular basis of subtype-selective cyclophilin inhibitors.
Nat Chem Biol
; 18(11): 1184-1195, 2022 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-36163383
3.
A MAPK scaffold lends a helping hand.
Cell
; 136(6): 994-6, 2009 Mar 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-19303841
4.
Mutation in Abl kinase with altered drug-binding kinetics indicates a novel mechanism of imatinib resistance.
Proc Natl Acad Sci U S A
; 118(46)2021 11 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-34750265
5.
Biochemical Studies of Systemic Lupus Erythematosus-Associated Mutations in Nonreceptor Tyrosine Kinases Ack1 and Brk.
Biochemistry
; 62(6): 1124-1137, 2023 03 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-36854171
6.
Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks.
J Biol Chem
; 298(8): 102268, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35850305
7.
Allosteric regulation and inhibition of protein kinases.
Biochem Soc Trans
; 51(1): 373-385, 2023 02 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-36794774
8.
Structural basis for the recognition of c-Src by its inactivator Csk.
Cell
; 134(1): 124-34, 2008 Jul 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-18614016
9.
Protein Flexibility and Dissociation Pathway Differentiation Can Explain Onset of Resistance Mutations in Kinases.
Angew Chem Int Ed Engl
; 61(28): e202200983, 2022 07 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-35486370
10.
Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.
Nat Chem Biol
; 15(6): 565-574, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31086331
11.
Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones.
Nature
; 511(7507): 94-8, 2014 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24847884
12.
Catalytic control in the EGF receptor and its connection to general kinase regulatory mechanisms.
Mol Cell
; 42(1): 9-22, 2011 Apr 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-21474065
13.
An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression.
Biochemistry
; 57(31): 4675-4689, 2018 08 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-30004690
14.
Enzymatic Activity and Thermodynamic Stability of Biliverdin IXß Reductase Are Maintained by an Active Site Serine.
Chemistry
; 23(8): 1891-1900, 2017 Feb 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-27897348
15.
A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.
Nature
; 472(7342): 238-42, 2011 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-21441902
16.
A novel activating, germline JAK2 mutation, JAK2R564Q, causes familial essential thrombocytosis.
Blood
; 123(7): 1059-68, 2014 Feb 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-24381227
17.
Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles.
Nat Chem Biol
; 8(4): 366-74, 2012 Feb 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-22344177
18.
Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors.
Nat Chem Biol
; 8(12): 982-9, 2012 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-23086298
19.
All the mutations that are fit to die.
Cell Chem Biol
; 31(2): 192-194, 2024 Feb 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38364776
20.
Calculating Protein-Ligand Residence Times Through State Predictive Information Bottleneck based Enhanced Sampling.
bioRxiv
; 2024 Apr 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38659748