Detalhe da pesquisa
1.
Structures of the cGMP-dependent protein kinase in malaria parasites reveal a unique structural relay mechanism for activation.
Proc Natl Acad Sci U S A
; 116(28): 14164-14173, 2019 07 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31239348
2.
The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Nat Chem Biol
; 13(4): 389-395, 2017 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-28135237
3.
Conformational dynamics of the TTD-PHD histone reader module of the UHRF1 epigenetic regulator reveals multiple histone-binding states, allosteric regulation, and druggability.
J Biol Chem
; 292(51): 20947-20959, 2017 12 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29074623
4.
A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.
Nat Chem Biol
; 12(3): 180-7, 2016 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-26807715
5.
Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
Nat Chem Biol
; 11(8): 571-578, 2015 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-26167872
6.
(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells.
Proc Natl Acad Sci U S A
; 111(35): 12853-8, 2014 Sep 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-25136132
7.
Addendum: A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1.
Nat Chem Biol
; 15(8): 846, 2019 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-30842648
8.
Trimethylation of histone H3 lysine 36 by human methyltransferase PRDM9 protein.
J Biol Chem
; 289(17): 12177-12188, 2014 Apr 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-24634223
9.
Erratum: The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex.
Nat Chem Biol
; 13(8): 922, 2017 Jul 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-28853738
10.
Small-molecule inhibition of MLL activity by disruption of its interaction with WDR5.
Biochem J
; 449(1): 151-9, 2013 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22989411
11.
Phosphorylation-independent dual-site binding of the FHA domain of KIF13 mediates phosphoinositide transport via centaurin alpha1.
Proc Natl Acad Sci U S A
; 107(47): 20346-51, 2010 Nov 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-21057110
12.
Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia.
Nat Chem Biol
; 11(10): 815, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26379026
13.
Structural and mechanistic analysis of a novel class of shikimate dehydrogenases: evidence for a conserved catalytic mechanism in the shikimate dehydrogenase family.
Biochemistry
; 50(40): 8616-27, 2011 Oct 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-21846128
14.
The Cryptosporidium parvum kinome.
BMC Genomics
; 12: 478, 2011 Sep 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-21962082
15.
Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid.
ChemMedChem
; 16(19): 2982-3002, 2021 10 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-34164919
16.
Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation.
ACS Med Chem Lett
; 12(6): 887-892, 2021 Jun 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34141066
17.
Biophysical characterization of recombinant proteins: a key to higher structural genomics success.
J Struct Biol
; 172(1): 107-19, 2010 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-20466062
18.
A survey of proteins encoded by non-synonymous single nucleotide polymorphisms reveals a significant fraction with altered stability and activity.
Biochem J
; 424(1): 15-26, 2009 Oct 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-19702579
19.
Application of high-throughput isothermal denaturation to assess protein stability and screen for ligands.
J Biomol Screen
; 13(5): 337-42, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18448703
20.
Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain.
SLAS Discov
; 23(9): 930-940, 2018 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-29562800