Detalhe da pesquisa
1.
Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.
Proc Natl Acad Sci U S A
; 120(1): e2211297120, 2023 01 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-36574664
2.
Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors.
J Med Chem
; 66(24): 16783-16806, 2023 12 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-38085679
3.
BIIB021, an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90.
Mol Cancer Ther
; 8(4): 921-9, 2009 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-19372565
4.
Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
J Med Chem
; 63(2): 656-675, 2020 01 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-31858797
5.
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer.
J Med Chem
; 62(8): 3971-3988, 2019 04 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-30929420
6.
Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design.
J Med Chem
; 61(6): 2410-2421, 2018 03 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-29323899
7.
Rationally designed high-affinity 2-amino-6-halopurine heat shock protein 90 inhibitors that exhibit potent antitumor activity.
J Med Chem
; 50(12): 2767-78, 2007 Jun 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-17488003
8.
Discovery and biological characterization of potent myeloid cell leukemia-1 inhibitors.
FEBS Lett
; 591(1): 240-251, 2017 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-27878989
9.
7'-substituted benzothiazolothio- and pyridinothiazolothio-purines as potent heat shock protein 90 inhibitors.
J Med Chem
; 49(17): 5352-62, 2006 Aug 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-16913725
10.
Orally active purine-based inhibitors of the heat shock protein 90.
J Med Chem
; 49(2): 817-28, 2006 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-16420067
11.
Discovery of 2-Indole-acylsulfonamide Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors Using Fragment-Based Methods.
J Med Chem
; 59(5): 2054-66, 2016 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-26878343