Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 7 de 7
Filtrar
1.
Br J Nutr ; 128(10): 1938-1945, 2022 11 28.
Artigo em Inglês | MEDLINE | ID: mdl-34865663

RESUMO

This research evaluates the prevalence of inadequate folate status in early pregnancy, the pattern of prenatal folic acid (FA) supplementation and associated factors in Spanish pregnant women from the ECLIPSES study, which included 791 participants prior gestational week 12. A cross-sectional evaluation of erythrocyte folate levels was performed at recruitment and used to calculate the prevalence of folate deficiency (erythrocyte folate < 340 nmol/l) and insufficiency (erythrocyte folate < 906 nmol/l). Sociodemographic and lifestyle data as well as information on prenatal FA supplementation were recorded. Descriptive and multivariate statistical analyses were performed. The prevalence of folate deficiency and insufficiency were 9·6 % and 86·5 %, respectively. Most of women used prenatal FA supplements, but only 6·3 % did so as recommended. Supplementation with FA during the periconceptional period abolished folate deficiency and reduced folate insufficiency. Prenatal FA supplementation with ≥1000 µg/d in periconceptional time and pregnancy planning increased erythrocyte folate levels. The main risk factor for folate insufficiency in early pregnancy was getting prenatal FA supplementation out of the periconceptional time (OR 3·32, 95 % CI 1·02, 15·36), while for folate deficiency they were young age (OR 2·02, 95 % CI 1·05, 3·99), and smoking (OR 2·39, 95 % CI 1·30, 4·37). In addition, social and ethnic differences according to folate status were also identified. As conclusion, periconceptional FA use is crucial for achieving optimal folate levels in early pregnancy. Pregnancy planning should focus on young women, smokers, those with low consumption of folate-rich foods, low socio-economic status or from ethnic minorities.


Assuntos
Deficiência de Ácido Fólico , Defeitos do Tubo Neural , Feminino , Gravidez , Humanos , Ácido Fólico , Estudos Transversais , Vitaminas , Suplementos Nutricionais , Gestantes , Defeitos do Tubo Neural/epidemiologia
2.
Clin Chem Lab Med ; 56(3): 403-412, 2018 02 23.
Artigo em Inglês | MEDLINE | ID: mdl-29055937

RESUMO

BACKGROUND: There is no consensus in the literature about what analytes or values should be informed as critical results and how they should be communicated. The main aim of this project is to establish consensual standards of critical results for the laboratories participating in the study. Among the project's secondary objectives, establishing consensual procedures for communication can be highlighted. METHODS: Consensus was reached among all participating laboratories establishing the basis for the construction of the initial model put forward for consensus in conjunction with the clinicians. A real-time Delphi, methodology "health consensus" (HC), with motivating and participative questions was applied. The physician was expected to choose a numeric value within a scale designed for each analyte. RESULTS: The medians of critical results obtained represent the consensus on critical results for outpatient and inpatient care. Both in primary care and in hospital care a high degree of consensus was observed for critical values proposed in the analysis of creatinine, digoxin, phosphorus, glucose, international normalized ratio (INR), leukocytes, magnesium, neutrophils, chloride, sodium, calcium and lithium. For the rest of critical results the degree of consensus obtained was "medium high". The results obtained showed that in 72% of cases the consensual critical value coincided with the medians initially proposed by the laboratories. CONCLUSIONS: The real-time Delphi has allowed obtaining consensual standards for communication of critical results among the laboratories participating in the study, which can serve as a basis for other organizations.


Assuntos
Técnicas de Laboratório Clínico , Técnica Delphi , Inteligência , Consenso , Humanos , Coeficiente Internacional Normatizado
3.
BMC Pregnancy Childbirth ; 14: 33, 2014 Jan 18.
Artigo em Inglês | MEDLINE | ID: mdl-24438754

RESUMO

BACKGROUND: Currently, there is no consensus regarding iron supplementation dose that is most beneficial for maternal and offspring health during gestation. Recommended iron supplementation dose does not preempt anemia in around 20% of the pregnancies, nor the risk of hemoconcentration in 15%. This deficit, or excess, of iron prejudices the mother-child wellbeing. Therefore the aims of the study are to determine the highest level of effectiveness of iron supplementation adapted to hemoglobin (Hb) levels in early pregnancy, which would be optimum for mother-child health. DESIGN: Randomized Clinical Trial (RCT) triple-blindedSetting: 10 Primary Care Centers from Catalunya (Spain)Study subjects: 878 non-anemic pregnant women at early gestation stage, and their subsequent newborns METHODS: The study is structured as a RCT with 2 strata, depending on the Hb levels before week 12 of gestation. Stratum #1: If Hb from 110 to 130 g/L, randomly assigned at week 12 to receive iron supplement of 40 or 80 mg/d. Stratum #2: If Hb >130 g/L, randomly assigned at week 12 to receive iron supplement of 40 or 20 mg/d. MEASUREMENTS: In the mother: socio-economic data, clinical history, food item frequency, lifestyle and emotional state, and adherence to iron supplement prescription. Biochemical measurements include: Hb, serum ferritin, C reactive protein, cortisol, and alterations in the HFE gene (C282Y, H63D). In children: ultrasound fetal biometry, anthropometric measurements, and temperament development.Statistical analyses, using the SPSS program for Windows, will include bivariate and multivariate analyses adjusted for variables associated with the relationship under study. DISCUSSION: Should conclusive outcomes be reached, the study would indicate the optimal iron supplementation dose required to promote maternal and infant health. These results would contribute towards developing guidelines for good clinical practice.


Assuntos
Anemia Ferropriva/prevenção & controle , Peso ao Nascer , Suplementos Nutricionais , Hemoglobinas/metabolismo , Ferro/administração & dosagem , Complicações Hematológicas na Gravidez/prevenção & controle , Adulto , Anemia Ferropriva/sangue , Antropometria , Proteína C-Reativa/metabolismo , Dieta , Suplementos Nutricionais/efeitos adversos , Relação Dose-Resposta a Droga , Feminino , Ferritinas/sangue , Desenvolvimento Fetal , Proteína da Hemocromatose , Antígenos de Histocompatibilidade Classe I/genética , Humanos , Hidrocortisona/sangue , Recém-Nascido , Ferro/efeitos adversos , Estilo de Vida , Adesão à Medicação , Proteínas de Membrana/genética , Gravidez , Projetos de Pesquisa , Temperamento , Ultrassonografia Pré-Natal , Adulto Jovem
4.
Nutrients ; 12(10)2020 Oct 19.
Artigo em Inglês | MEDLINE | ID: mdl-33086652

RESUMO

Vitamin D status during pregnancy is involved in numerous physiological processes, including brain development. In this study, we assess the association between vitamin D status during pregnancy and infant neurodevelopment (cognitive, language, and motor skills). From an initial sample of 793 women (mean age 30.6) recruited before the 12th week of pregnancy, 422 mother-infant pairs were followed up to a postpartum visit. Vitamin D levels were assessed in the first and third trimesters of pregnancy, and socio-demographic, nutritional, and psychological variables were collected. At 40 days postpartum, the Bayley Scales of Infant Development-III were administered to the infants and several obstetrical data were recorded. Independently from several confounding factors, deficient vitamin D levels in the first trimester of pregnancy (<30 nmol/L) predicted a worse performance in cognitive and language skills. Language performance worsened with lower vitamin D levels (<20 nmol/L). In the third trimester, this highly deficient level was also associated with lower motor skills. Vitamin D deficiency was therefore associated with worse neurodevelopmental outcomes. More studies are needed to determine specific recommendations with regard to vitamin D supplementation during pregnancy in order to promote an optimal course for pregnancy and optimal infant neurodevelopment.


Assuntos
Desenvolvimento Infantil/fisiologia , Suplementos Nutricionais , Desenvolvimento Fetal/fisiologia , Fenômenos Fisiológicos da Nutrição Materna/fisiologia , Troca Materno-Fetal/fisiologia , Transtornos do Neurodesenvolvimento/prevenção & controle , Estado Nutricional , Fenômenos Fisiológicos da Nutrição Pré-Natal/fisiologia , Vitamina D/administração & dosagem , Adulto , Feminino , Humanos , Lactente , Recém-Nascido , Transtornos do Neurodesenvolvimento/etiologia , Gravidez , Deficiência de Vitamina D/complicações , Adulto Jovem
5.
Sci Rep ; 10(1): 15757, 2020 09 25.
Artigo em Inglês | MEDLINE | ID: mdl-32978425

RESUMO

The hypovitaminosis D epidemic is a global health problem. Our aim was to assess the prevalence and potential risk factors of hypovitaminosis D among pregnant women on the eastern Mediterranean coast. Cross-sectional analysis involved 793 healthy pregnant women (35.3 ± 5.0 years) participating in ECLIPSES, a multicenter randomized trial. Socio-demographic, obstetric, anthropometric, lifestyle, dietary variables and blood draw was collected in the first trimester. Vitamin D deficiency was identified in 50.2% and insufficiency in 30.3% of pregnant women. The mean vitamin D level in the overall sample was 33.9 nmol/L (SD, 17.0). Multivariable logistic regression analysis applying AIC-based backward selection identified excess weight during the 1st trimester (BMI ≥ 25 kg/m2) (OR = 1.950, 95% CI = 1.409, 2.699), Arab ethnic group/dark skin colour (OR = 4.005, 95% CI = 2.488, 6.447), winter/spring (OR = 4.319, 95% CI = 3.112, 5.994), and consumption of milk (OR = 0.754, 95% CI = 0.572, 0.993) and yogurt (OR = 0.635, 95% CI = 0.436, 0.922) as independent risk factors for vitamin D deficiency. All of these factors (except yogurt consumption) and physical activity were independently associated with vitamin D deficiency/insufficiency risk in the final multivariable model (all p < 0.05). All these factors and social class were the most important determinants of circulating 25(OH)D concentrations. Our results confirm a high prevalence of vitamin D deficiency and insufficiency among pregnant women from the eastern Mediterranean coast.


Assuntos
Complicações na Gravidez/epidemiologia , Deficiência de Vitamina D/epidemiologia , Adulto , Estudos Transversais , Feminino , Humanos , Gravidez , Prevalência , Vitamina D/sangue
6.
Nutrients ; 11(10)2019 Oct 10.
Artigo em Inglês | MEDLINE | ID: mdl-31658725

RESUMO

Iron deficiency (ID), anemia, iron deficiency anemia (IDA) and excess iron (hemoconcentration) harm maternal-fetal health. We evaluated the effectiveness of different doses of iron supplementation adjusted for the initial levels of hemoglobin (Hb) on maternal iron status and described some associated prenatal determinants. The ECLIPSES study included 791 women, randomized into two groups: Stratum 1 (Hb = 110-130g/L, received 40 or 80mg iron daily) and Stratum 2 (Hb > 130g/L, received 20 or 40mg iron daily). Clinical, biochemical, and genetic information was collected during pregnancy, as were lifestyle and sociodemographic characteristics. In Stratum 1, using 80 mg/d instead of 40 mg/d protected against ID on week 36. Only women with ID on week 12 benefited from the protection against anemia and IDA by increasing Hb levels. In Stratum 2, using 20 mg/d instead of 40 mg/d reduced the risk of hemoconcentration in women with initial serum ferritin (SF) ≥ 15 µg/L, while 40 mg/d improved SF levels on week 36 in women with ID in early pregnancy. Mutations in the HFE gene increased the risk of hemoconcentration. Iron supplementation should be adjusted to early pregnancy levels of Hb and iron stores. Mutations of the HFE gene should be evaluated in women with high Hb levels in early pregnancy.


Assuntos
Anemia Ferropriva , Ferro/administração & dosagem , Ferro/uso terapêutico , Complicações Hematológicas na Gravidez , Adulto , Anemia Ferropriva/tratamento farmacológico , Anemia Ferropriva/prevenção & controle , Suplementos Nutricionais , Feminino , Ferritinas/sangue , Proteína da Hemocromatose/genética , Hemoglobinas/análise , Humanos , Gravidez , Complicações Hematológicas na Gravidez/tratamento farmacológico , Complicações Hematológicas na Gravidez/prevenção & controle , Cuidado Pré-Natal , Espanha , Resultado do Tratamento , Adulto Jovem
7.
Rev. lab. clín ; 8(2): 61-66, abr.-jun. 2015. tab
Artigo em Espanhol | IBECS (Espanha) | ID: ibc-137609

RESUMO

Introducción. La hemólisis, la turbidez y la presencia de concentraciones elevadas de bilirrubina son las fuentes de interferencia más frecuentes en el laboratorio clínico. Muchos analizadores incorporan sistemas de detección de estos interferentes denominados «índices séricos» de hemólisis, ictericia y lipidemia. El grado de veracidad de los índices no suele ser verificado por la dificultad en conseguir materiales de referencia adecuados. En este trabajo se presentan los resultados de un estudio interlaboratorios de los índices hemólisis, ictericia y lipidemia empleando materiales de referencia con concentraciones conocidas de los interferentes. Material y métodos. En el estudio han participado los laboratorios clínicos de 10 centros con 7 analizadores distintos. Los materiales de referencia de índices séricos contenían concentraciones conocidas de bilirrubina, hemoglobina (hemolisado) y triglicéridos (Intralipid). Resultados. Todos los instrumentos proporcionaron resultados aceptables para el índice de ictericia y de hemólisis. Entre los analizadores que dan valores cuantitativos se encontraron resultados bajos en uno de los analizadores para los materiales que contenían Intralipid. Los analizadores que expresan el resultado en forma de un intervalo proporcionaron resultados correctos para los materiales con turbidez menor y bajos para el material con turbidez mayor. Conclusiones. Los materiales de referencia utilizados han demostrado su utilidad para verificar los índices séricos de ictericia, hemólisis y lipidemia en los analizadores. Generalmente los índices proporcionados por los instrumentos concuerdan entre sí y con los valores asignados. Las diferencias más importantes entre analizadores se encuentran en el índice de lipidemia (AU)


Introduction. Hemolysis, turbidity and the presence of high concentrations of bilirubin are the most frequent sources of interference in the clinical laboratory. Many analyzers incorporate detection systems for these interferents called “serum indexes” of hemolysis, icterus and lipidemia. The accuracy of such indexes is usually not verified by the difficulty in obtaining appropriate reference materials. In this work we show the results of an interlaboratory study of hemolysis, icterus and lipidemia indexes using reference materials containing known concentrations of these interfering substances. Material and methods. Ten clinical laboratories from different centres have participated in the study using 7 different analyzers. The reference materials for the serum indexes contained known concentrations of bilirubin, hemoglobin (hemolysate) and triglycerides (Intralipid). Results. All instruments provided acceptable results for the icterus and hemolysis index. Among the analyzers providing quantitative values, low results were found in one of the analyzers for materials containing Intralipid. The analyzers expressing the result as an interval provided correct results for materials with low turbidity but a low result for the material with the highest turbidity. Conclusions. The reference materials used have proved to be useful to verify the serum indexes for hemolysis, icterus and lipidemia in analyzers. The results obtained in different instruments generally agree among them and with the assigned values. The most important differences between analyzers were found in the lipidemia index (AU)


Assuntos
Feminino , Humanos , Masculino , Ciência de Laboratório Médico/métodos , Técnicas de Laboratório Clínico/métodos , Técnicas de Laboratório Clínico/normas , Controle de Qualidade , Lipase Lipoproteica/análise , Icterícia/diagnóstico , Padrões de Referência , Biomarcadores/análise , Ensaios de Anticorpos Bactericidas Séricos/ética , Hemólise
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA