Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 3 de 3
Filtrar
1.
South Med J ; 104(1): 40-5, 2011 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-21119555

RESUMO

Klebsiella pneumoniae carbapenemase (KPC)-producing bacteria are a group of emerging highly drug-resistant Gram-negative bacilli causing infections associated with significant morbidity and mortality. Once confined to outbreaks in the northeastern United States (US), they have spread throughout the US and most of the world. KPCs are an important mechanism of resistance for an increasingly wide range of Gram-negative bacteria and are no longer limited to K pneumoniae. KPC-producing bacteria are often misidentified by routine microbiological susceptibility testing and incorrectly reported as sensitive to carbapenems; however, resistance to the carbapenem antibiotic ertapenem is common and a better indicator of the presence of KPCs. Carbapenem antibiotics are generally not effective against KPC-producing organisms. The best therapeutic approach to KPC-producing organisms has yet to be defined; however, common treatments based on in vitro susceptibility testing are the polymyxins, tigecycline, and less frequently, aminoglycoside antibiotics. The purpose of this review is to identify the various challenges that KPC-producing bacteria present to clinicians. These include the need for special techniques for microbiological detection, the potential for nosocomial transmission, and therapeutic challenges related to limited, relatively unproven antimicrobial treatment options.


Assuntos
Antibacterianos/uso terapêutico , Proteínas de Bactérias/biossíntese , Técnicas Bacteriológicas/métodos , Infecções por Klebsiella , Klebsiella pneumoniae/enzimologia , beta-Lactamases/biossíntese , Proteínas de Bactérias/análise , Diagnóstico Diferencial , Humanos , Infecções por Klebsiella/diagnóstico , Infecções por Klebsiella/tratamento farmacológico , Infecções por Klebsiella/microbiologia , Klebsiella pneumoniae/isolamento & purificação , Metaloproteínas , beta-Lactamases/análise
2.
J Antimicrob Chemother ; 65(4): 775-83, 2010 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-20150181

RESUMO

UNLABELLED: Rationale Linezolid may be effective for the treatment of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis (TB); however, serious adverse events are common and there is little information on the management of these toxicities. METHODS: We retrospectively reviewed public health and medical records of 16 MDR TB patients, including 10 patients with XDR TB, who were treated with linezolid in New York City between January 2000 and December 2006, to determine treatment outcomes and describe the incidence, management and predictors of adverse events. RESULTS: Linezolid was added to MDR TB regimens for a median duration of 16 months (range: 1-29). Eleven patients (69%) completed treatment, four (25%) died and one (6%) discontinued treatment without relapse. Myelosuppression occurred in 13 (81%) patients a median of 5 weeks (range: 1-11) after starting linezolid, gastrointestinal adverse events occurred in 13 (81%) patients after a median of 8 weeks (range: 1-57) and neurotoxicity occurred in seven (44%) patients after a median of 16 weeks (range: 10-111). Adverse events were managed by combinations of temporary suspension of linezolid, linezolid dose reduction and symptom management. Five (31%) patients required eventual discontinuation of linezolid. Myelosuppression was more responsive to clinical management strategies than was neurotoxicity. Leucopenia and neuropathy occurred more often in males and older age was associated with thrombocytopenia (P < 0.05). CONCLUSIONS: The majority of MDR TB patients on linezolid had favourable treatment outcomes, although treatment was complicated by adverse events that required extensive clinical management.


Assuntos
Acetamidas/efeitos adversos , Acetamidas/uso terapêutico , Antituberculosos/efeitos adversos , Antituberculosos/uso terapêutico , Oxazolidinonas/efeitos adversos , Oxazolidinonas/uso terapêutico , Tuberculose Resistente a Múltiplos Medicamentos/tratamento farmacológico , Adulto , Idoso , Doenças da Medula Óssea/induzido quimicamente , Criança , Feminino , Gastroenteropatias/induzido quimicamente , Humanos , Incidência , Linezolida , Masculino , Pessoa de Meia-Idade , Doenças do Sistema Nervoso/induzido quimicamente , Cidade de Nova Iorque , Estudos Retrospectivos , Resultado do Tratamento , Adulto Jovem
3.
Infect Control Hosp Epidemiol ; 34(8): 809-17, 2013 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-23838221

RESUMO

OBJECTIVE: To describe the epidemiology of carbapenem-resistant Enterobacteriaceae (CRE) carriage and acquisition among hospitalized patients in an area of CRE endemicity. DESIGN: Cohort study with a nested case-control study. SETTING: Two acute care, academic hospitals in New York City. PARTICIPANTS: All patients admitted to 7 study units, including intensive care, medical-surgical, and acute rehabilitation units. METHOD: Perianal samples were collected from patients at admission and weekly thereafter to detect asymptomatic gastrointestinal carriage of CRE. A nested case-control study was performed to identify factors associated with CRE acquisition. Case patients were those who acquired CRE during a single hospitalization. Control subjects had no microbiologic evidence of CRE and at least 1 negative surveillance sample. Clinical data were abstracted from the medical record. RESULTS: The prevalence of CRE in the study population was 5.4% (306 of 5,676 patients), and 104 patients met the case definition of acquisition during a single hospital stay. Mechanical ventilation (odds ratio [OR], 11.5), pulmonary disease (OR, 5.2), days of antibiotic therapy (OR, 1.04), and CRE colonization pressure (OR, 1.15) were independently associated with CRE acquisition. Pulsed-field gel electrophoresis analysis identified 87% of tested Klebsiella pneumoniae isolates as sharing related patterns (greater than 78% similarity), which suggests clonal transmission within and between the study hospitals. CONCLUSIONS: Critical illness and underlying medical conditions, CRE colonization pressure, and antimicrobial exposure are important risk factors for CRE acquisition. Adherence to infection control practices and antimicrobial stewardship appear to be critical components of a CRE control program.


Assuntos
Carbapenêmicos , Portador Sadio/epidemiologia , Infecção Hospitalar/epidemiologia , Doenças Endêmicas , Infecções por Klebsiella/epidemiologia , Klebsiella pneumoniae/isolamento & purificação , Resistência beta-Lactâmica , Adulto , Idoso , Idoso de 80 Anos ou mais , Canal Anal/microbiologia , Portador Sadio/microbiologia , Estudos de Casos e Controles , Infecção Hospitalar/microbiologia , Eletroforese em Gel de Campo Pulsado , Feminino , Hospitais Universitários , Hospitais Urbanos , Humanos , Infecções por Klebsiella/microbiologia , Pneumopatias/complicações , Masculino , Pessoa de Meia-Idade , Cidade de Nova Iorque/epidemiologia , Prevalência , Respiração Artificial/efeitos adversos , Fatores de Risco , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA