[Analysis of the electrophysiologic characteristics of the trabecular membrane in the atria of frogs by recording ionic currents during potential fixation. II. Accomodation. Repeated responses. Anode-breaking excitation]. / Analiz élektrofiziologicheskikh kharakteristik membrany trabekuly predserdiia liagushki po zapisiam ionnykh tokov pri fiksatsii potentsiala. II. Akkomodatsiia. Povtornye otvety. Andonorazmykatel'noe vozbuzhdenie

Measurements were carried out by the method of double succrose gap. Accommodation was practically absent in all the preparations studied: the minimal gradient was not observed, the mean value of accommodation was 0.02 rheobasa/s, saturation current/H practically coincided with the current of rheobase IO(IH/IO = 1.0 +/- 0.1). Repeated responses were initiated in 1/3 of samples. The current of initiating the repeated responses IRR was insignificantly higher than the rheobase one (IRR/IO = 1.2 +/- 0.1). In the samples where the replated responses were absent the effect of uneven depolarization was observed. At depolarization current which was insignificantly higher than the threshold one (IO), the potential did not return to the resting potential and was settled at the level of -20 mV. Anode disconnecting excitation was absent in all the samples. The hyperpolarization level varied from -90 to -160 mV. The data obtained well agree with the results of the analysis of the mathematical model of frog auricle trabecula membrane constructed on the basis of the data on the potential fixation.

[Assessment of the use of various cardiac pacing modes for selection of antiarrhythmic therapy for prevention of recurrent attacks of atrial fibrillation and flutter]. / Otsenka ispol'zovaniia razlichnykh rezhimov kardiostimuliatsii dlia opredeleniia protivoretsidivnoi antiaritmicheskoi terapii paroksizmov mertsaniia i trepetaniia predserdii

AIM: To determine optimal mode of transesophageal pacing for selection of appropriate antiarrhythmic therapy for prevention of attacks of atrial fibrillation and flutter in patients with ischemic heart disease. MATERIAL AND METHODS: Two hundred eighteen patients with ischemic heart disease and attacks of atrial fibrillation or flutter. Selection of antiarrhythmic drugs was carried out with the use of competitive, rapid, salvos of ultra rapid, and slowly accelerating ultra rapid modes of pacing. Results. Most effective and reproducible method for induction of attacks of atrial flutter and fibrillation was slowly accelerating ultra rapid mode of pacing. Average duration of positive clinical effect of preventive antiarrhythmic therapy selected basing on the results of this mode in patients with ischemic heart disease was 3.1-/+0.3 years. Unfavorable prognostic sign decreasing preventive effect of antiarrhythmic therapy was left atrial dilatation. CONCLUSION: Slowly accelerating mode of transesophageal pacing was most effective tool for selection of antiarrhythmic therapy aimed at prevention of attacks of atrial fibrillation and flutter in patients with ischemic heart disease.