Rumination and the default mode network: Meta-analysis of brain imaging studies and implications for depression.

Rumination is strongly and consistently correlated with depression. Although multiple studies have explored the neural correlates of rumination, findings have been inconsistent and the mechanisms underlying rumination remain elusive. Functional brain imaging studies have identified areas in the default mode network (DMN) that appear to be critically involved in ruminative processes. However, a meta-analysis to synthesize the findings of brain regions underlying rumination is currently lacking. Here, we conducted a meta-analysis consisting of experimental tasks that investigate rumination by using Signed Differential Mapping of 14 fMRI studies comprising 286 healthy participants. Furthermore, rather than treat the DMN as a unitary network, we examined the contribution of three DMN subsystems to rumination. Results confirm the suspected association between rumination and DMN activation, specifically implicating the DMN core regions and the dorsal medial prefrontal cortex subsystem. Based on these findings, we suggest a hypothesis of how DMN regions support rumination and present the implications of this model for treating major depressive disorder characterized by rumination.

The subsystem mechanism of default mode network underlying rumination: A reproducible neuroimaging study.

Rumination is a repetitive self-referential thinking style that is often interpreted as an expression of abnormalities of the default mode network (DMN) observed during "resting-state" in major depressive disorder (MDD). Recent evidence has demonstrated that the DMN is not unitary but can be further divided into 3 functionally heterogenous subsystems, although the subsystem mechanistically underlying rumination remains unclear. Due to the unconstrained and indirect correlational nature of previous resting-state fMRI studies on rumination's network underpinnings, a paradigm allowing direct investigation of network interactions during active rumination is needed. Here, with a modified continuous state-like paradigm, we induced healthy participants to ruminate or imagine objective scenarios (distraction, as a control condition) on 3 different MRI scanners. We compared functional connectivities (FC) of the DMN and its 3 subsystems between rumination and distraction states. Results yielded a highly reproducible and dissociated pattern. During rumination, within-DMN FC was generally decreased as compared to the distraction state. At the subsystem level, we found increased FC between the core and medial temporal lobe (MTL) subsystem as well as decreased FC between the core and dorsal medial prefrontal cortex (DMPFC) subsystem and within the MTL subsystem. Finally, subjects' behavioral measures of rumination and brooding were negatively correlated with FC between the core and DMPFC subsystems. These results suggest active rumination involves enhanced constraint by the core subsystem on the MTL subsystem and decreased coupling between the core and DMPFC subsystem, allowing for more information exchange among those involved DMN components. Furthermore, the reproducibility of our findings provides a rigorous evaluation of their validity and significance.

Parent Perceptions of the Effects of Early Intensive Behavioral Interventions for Children with Autism.

The current study aimed to understand parents' perceptions of the effects of early intensive behavioral intervention (EIBI) based on the principles of applied behavioral analysis (ABA) and the lasting outcomes for their children with Autism spectrum disorder (ASD). In particular, this study sought to examine parent perceptions of the relationship between the intensity of ABA interventions and current autism symptom severity, adaptive functioning, and school placement. The current study employed a convergent parallel mixed-methods design, which consisted of collecting, analyzing, interpreting, and combining both quantitative and qualitative data. Overall, results suggested that the intensity of previous ABA interventions was a unique predictor of current school placement. Additionally, results suggested that the intensity of previous ABA interventions was a unique predictor of adaptive skills, which was supported by parent interviews. However, the intensity of previous ABA interventions was not a unique predictor of current autism severity. Parent responses to interview questions revealed the imperative nature of the interventions and their effect on service delivery for their children with ASD. Overall, this study provided an increased understanding of parents' perceptions of the effectiveness of EIBI, which in turn may be central to understanding service utilization.

Gender Difference in Psychological, Cognitive, and Behavioral Patterns Among University Students During COVID-19: A Machine Learning Approach.

The COVID-19 pandemic affects all population segments and is especially detrimental to university students because social interaction is critical for a rewarding campus life and valuable learning experiences. In particular, with the suspension of in-person activities and the adoption of virtual teaching modalities, university students face drastic changes in their physical activities, academic careers, and mental health. Our study applies a machine learning approach to explore the gender differences among U.S. university students in response to the global pandemic. Leveraging a proprietary survey dataset collected from 322 U.S. university students, we employ association rule mining (ARM) techniques to identify and compare psychological, cognitive, and behavioral patterns among male and female participants. To formulate our task under the conventional ARM framework, we model each unique question-answer pair of the survey questionnaire as a market basket item. Consequently, each participant's survey report is analogous to a customer's transaction on a collection of items. Our findings suggest that significant differences exist between the two gender groups in psychological distress and coping strategies. In addition, the two groups exhibit minor differences in cognitive patterns and consistent preventive behaviors. The identified gender differences could help professional institutions to facilitate customized advising or counseling for males and females in periods of unprecedented challenges.

Different Coping Patterns among US Graduate and Undergraduate Students during COVID-19 Pandemic: A Machine Learning Approach.

COVID-19 caused unprecedented disruptions to regular university operations worldwide. Dealing with 100% virtual classrooms and suspension of essential in-person activities resulted in significant stress and anxiety for students coping with isolation, fear, and uncertainties in their academic careers. In this study, we applied a machine learning approach to identify distinct coping patterns between graduate and undergraduate students when facing these challenges. We based our study on a large proprietary dataset collected from 517 students in US professional institutions during an early peak of the pandemic. In particular, we cast our problem under the association rule mining (ARM) framework by introducing a new method to transform survey data into market basket items and customer transactions in which students' behavioral patterns were analogous to customer purchase patterns. Our experimental results suggested that graduate and undergraduate students adopted different ways of coping that could be attributed to their different maturity levels and lifestyles. Our findings can further serve as a focus of attention (FOA) tool to facilitate customized advising or counseling to address the unique challenges associated with each group that may warrant differentiated interventions.