The Correlation of Family Resilience with Sleep Quality and Depression of Parents of Children with Epilepsy.

PURPOSE: The present study aims to investigate the correlation between family resilience, sleep quality, and depression in parents of children with epilepsy. DESIGN AND METHODS: The parents of 157 children with epilepsy were assessed using the shortened Chinese version of the Family Resilience Assessment Scale (FRAS-SC) to measure the resilience level of families of children with epilepsy. The Pittsburgh Sleep Quality Index (PSQI) was used to determine the sleep quality of the subjects. The Self-Rating Depression Scale (SDS), a self-rating scale for evaluating depression, was used. RESULTS: The FRAS-SC total score was 97.9 ± 9.0. The PSQI total score was 6.41 ± 3.79, and the detection rate of sleep disorders was 37.6%. The SDS total score was 51.63 ± 10.73, and the detection rate of moderate-severe depressive symptoms was 21.6%. The FRAS-SC total score and all items (except USR) were negatively correlated with the PSQI total score (P < .05). The FRAS-SC total score and all items were significantly and negatively correlated with the SDS total score (P < .01). The degree of explanation of family resilience for sleep quality and depression was 3.5% and 14.9%, respectively. CONCLUSIONS: The higher the level of family resilience, the better sleep quality and the less depression the parents of children with epilepsy will get. PRACTICAL IMPLICATIONS: Relevant intervention measures based on family resilience will help to improve the sleep quality of parents of children with epilepsy and alleviate depression. And then improve the family's ability to care for children with epilepsy.

Clinical and EEG characteristics analysis of autoimmune encephalitis in children with positive and negative anti-N-methyl- D-aspartate receptor antibodies.

BACKGROUND: Autoimmune encephalitis is complex and varied, but it is a curable disease. However, the diagnosis and treatment of children with Autoimmune encephalitis remains challenging. Therefore, we conducted this study to analyze the clinical features, electroencephalogram (EEG) characteristics, treatment and prognosis of autoimmune encephalitis in children with negative and positive anti-N-methyl-D-aspartate receptor (NMDAR) antibody. METHODS: From January 2015 to January 2017, 28 child patients with autoimmune encephalitis were hospitalized in the Neural Ward of the Children's Medical Center, Qilu Hospital of Shandong University. Inclusion criteria were based on the diagnostic criteria for autoimmune encephalitis published in Lancet Neurology in 2016. The clinical, EEG and imaging data were summarized. The clinical features, treatment regimen, follow-up and prognosis were also analyzed. RESULTS: Among these 28 child patients, 10 patients had positive anti-NMDAR antibody, while 18 patients had negative anti-NMDAR antibody. The clinical manifestations, EEG findings and seizures were similar (P>0.05) between these two groups. All 28 child patients were treated with methylprednisolone shock and human immunoglobulin. The response to immunotherapy was similar between these two groups (P>0.05). CONCLUSIONS: The clinical manifestation of autoimmune encephalitis is complex and varied, but it is a curable disease. Immunotherapy should be considered as soon as possible, with or without autoantibodies. Most of the child patients had a good prognosis, while some of them had the sequelae of epilepsy, mild mental symptoms, and dyskinesia. It is necessary to improve the understanding of autoimmune encephalitis with/without positive antibodies, and make diagnosis and treatment as soon as possible, in order to improve the prognosis.