Detalhe da pesquisa
1.
Conditional Deletion of ß-Catenin in the Mediobasal Hypothalamus Impairs Adaptive Energy Expenditure in Response to High-Fat Diet and Exacerbates Diet-Induced Obesity.
J Neurosci
; 44(14)2024 Apr 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-38395612
2.
ß-Cells retain a pool of insulin-containing secretory vesicles regulated by adherens junctions and the cadherin-binding protein p120 catenin.
J Biol Chem
; 298(8): 102240, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35809641
3.
A role for PAK1 mediated phosphorylation of ß-catenin Ser552 in the regulation of insulin secretion.
Biochem J
; 478(8): 1605-1615, 2021 04 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33605402
4.
The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Maori and Pacific ancestry.
Diabetologia
; 64(12): 2779-2789, 2021 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-34417843
5.
ß-Catenin is required for optimal exercise- and contraction-stimulated skeletal muscle glucose uptake.
J Physiol
; 599(16): 3897-3912, 2021 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-34180063
6.
Diverse mechanisms activate the PI 3-kinase/mTOR pathway in melanomas: implications for the use of PI 3-kinase inhibitors to overcome resistance to inhibitors of BRAF and MEK.
BMC Cancer
; 21(1): 136, 2021 Feb 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-33549048
7.
α-catenin isoforms are regulated by glucose and involved in regulating insulin secretion in rat clonal ß-cell models.
Biochem J
; 477(4): 763-772, 2020 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-32003420
8.
The CSF1 receptor inhibitor pexidartinib (PLX3397) reduces tissue macrophage levels without affecting glucose homeostasis in mice.
Int J Obes (Lond)
; 44(1): 245-253, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30926949
9.
Variable-Length Ester-Based Staples for α-Helical Peptides by Using A Double Thiol-ene Reaction.
Chemistry
; 26(47): 10826-10833, 2020 Aug 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-32232881
10.
Synthesis and biological evaluation of solubilized sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.
Bioorg Med Chem
; 27(8): 1529-1545, 2019 04 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-30850264
11.
ß-catenin is important for the development of an insulin responsive pool of GLUT4 glucose transporters in 3T3-L1 adipocytes.
Exp Cell Res
; 366(1): 49-54, 2018 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29540328
12.
Discordant association of the CREBRF rs373863828 A allele with increased BMI and protection from type 2 diabetes in Maori and Pacific (Polynesian) people living in Aotearoa/New Zealand.
Diabetologia
; 61(7): 1603-1613, 2018 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-29721634
13.
Combining properties of different classes of PI3Kα inhibitors to understand the molecular features that confer selectivity.
Biochem J
; 474(13): 2261-2276, 2017 06 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-28526744
14.
A Critical Role for ß-Catenin in Modulating Levels of Insulin Secretion from ß-Cells by Regulating Actin Cytoskeleton and Insulin Vesicle Localization.
J Biol Chem
; 291(50): 25888-25900, 2016 Dec 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-27777306
15.
Novel pyrazolo[1,5-a]pyridines with improved aqueous solubility as p110α-selective PI3 kinase inhibitors.
Bioorg Med Chem Lett
; 27(2): 187-190, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27923617
16.
Synthesis and biological evaluation of sulfonamide analogues of the phosphatidylinositol 3-kinase inhibitor ZSTK474.
Bioorg Med Chem
; 25(20): 5859-5874, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28958845
17.
Niclosamide blocks glucagon phosphorylation of Ser552 on ß-catenin in primary rat hepatocytes via PKA signalling.
Biochem J
; 473(9): 1247-55, 2016 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26964897
18.
Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survival.
PLoS Biol
; 11(3): e1001515, 2013.
Artigo
em Inglês
| MEDLINE | ID: mdl-23526884
19.
Exploring the isoform selectivity of TGX-221 related pyrido[1,2-a]pyrimidinone-based Class IA PI 3-kinase inhibitors: synthesis, biological evaluation and molecular modelling.
Bioorg Med Chem
; 23(13): 3796-808, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25890698
20.
Structure, function and inhibition of the phosphoinositide 3-kinase p110α enzyme.
Biochem Soc Trans
; 42(1): 120-4, 2014 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-24450638