Detalhe da pesquisa
1.
Development of BET inhibitors as potential treatments for cancer: A search for structural diversity.
Bioorg Med Chem Lett
; 44: 128108, 2021 07 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33991625
2.
Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
Bioorg Med Chem Lett
; 51: 128376, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34560263
3.
Orally bioavailable amine-linked macrocyclic inhibitors of factor XIa.
Bioorg Med Chem Lett
; 30(4): 126949, 2020 02 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31932224
4.
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability.
Bioorg Med Chem Lett
; 29(19): 126604, 2019 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31445854
5.
Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors.
Bioorg Med Chem Lett
; 28(6): 987-992, 2018 04 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29501396
6.
Heterobicyclic inhibitors of transforming growth factor beta receptor I (TGFßRI).
Bioorg Med Chem
; 26(5): 1026-1034, 2018 03 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29422332
7.
Discovery and initial optimization of alkoxyanthranilic acid derivatives as inhibitors of HCV NS5B polymerase.
Bioorg Med Chem Lett
; 27(2): 295-298, 2017 01 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27908764
8.
Macrocyclic factor XIa inhibitors.
Bioorg Med Chem Lett
; 27(17): 4056-4060, 2017 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28780160
9.
Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency.
Bioorg Med Chem Lett
; 27(16): 3833-3839, 2017 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28687203
10.
Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group.
Bioorg Med Chem
; 24(10): 2257-72, 2016 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27073051
11.
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties.
Bioorg Med Chem Lett
; 25(7): 1635-42, 2015 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25728130
12.
Discovery of nonbenzamidine factor VIIa inhibitors using a biaryl acid scaffold.
Bioorg Med Chem Lett
; 23(18): 5239-43, 2013 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23927973
13.
Discovery of Milvexian, a High-Affinity, Orally Bioavailable Inhibitor of Factor XIa in Clinical Studies for Antithrombotic Therapy.
J Med Chem
; 65(3): 1770-1785, 2022 02 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-34494428
14.
Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties.
ACS Med Chem Lett
; 13(7): 1165-1171, 2022 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35859878
15.
Investigation of the mode of binding of a novel series of N-benzyl-4-heteroaryl-1-(phenylsulfonyl)piperazine-2-carboxamides to the hepatitis C virus polymerase.
Bioorg Med Chem Lett
; 21(8): 2212-5, 2011 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21441029
16.
Discovery of 3-hydroxy-4-cyano-isoquinolines as novel, potent, and selective inhibitors of human 11ß-hydroxydehydrogenase 1 (11ß-HSD1).
Bioorg Med Chem Lett
; 21(22): 6693-8, 2011 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21983444
17.
Syntheses and initial evaluation of a series of indolo-fused heterocyclic inhibitors of the polymerase enzyme (NS5B) of the hepatitis C virus.
Bioorg Med Chem Lett
; 21(10): 2925-9, 2011 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21486696
18.
Conserved core substructures in the overlay of protein-ligand complexes.
J Chem Inf Model
; 51(8): 1931-41, 2011 Aug 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-21736376
19.
Cloning, purification, crystallization and preliminary X-ray analysis of the catalytic domain of human receptor-like protein tyrosine phosphatase γ in three different crystal forms.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 67(Pt 7): 768-74, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21795790
20.
Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).
Acta Crystallogr F Struct Biol Commun
; 77(Pt 1): 22-28, 2021 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33439152