Detalhe da pesquisa
1.
Expression of Microcystis Biosynthetic Gene Clusters in Natural Populations Suggests Temporally Dynamic Synthesis of Novel and Known Secondary Metabolites in Western Lake Erie.
Appl Environ Microbiol
; 89(5): e0209222, 2023 05 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37070981
2.
Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubida.
Nucleic Acids Res
; 49(16): 9560-9573, 2021 09 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34417608
3.
Concanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes.
Proc Natl Acad Sci U S A
; 117(38): 23835-23846, 2020 09 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-32900948
4.
Molecular Dynamics Simulations Guide Chimeragenesis and Engineered Control of Chemoselectivity in Diketopiperazine Dimerases.
Angew Chem Int Ed Engl
; 62(20): e202210254, 2023 05 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-36610039
5.
Data Science-Driven Analysis of Substrate-Permissive Diketopiperazine Reverse Prenyltransferase NotF: Applications in Protein Engineering and Cascade Biocatalytic Synthesis of (-)-Eurotiumin A.
J Am Chem Soc
; 144(42): 19326-19336, 2022 10 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-36223664
6.
Metagenomic and Metatranscriptomic Insights into Population Diversity of Microcystis Blooms: Spatial and Temporal Dynamics of mcy Genotypes, Including a Partial Operon That Can Be Abundant and Expressed.
Appl Environ Microbiol
; 88(9): e0246421, 2022 05 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35438519
7.
Engineering sequence and selectivity of late-stage C-H oxidation in the MycG iterative cytochrome P450.
J Ind Microbiol Biotechnol
; 49(1)2022 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-34543433
8.
Perturbation of the interactions of calmodulin with GRK5 using a natural product chemical probe.
Proc Natl Acad Sci U S A
; 116(32): 15895-15900, 2019 08 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31337679
9.
Recent advances in hapalindole-type cyanobacterial alkaloids: biosynthesis, synthesis, and biological activity.
Nat Prod Rep
; 38(9): 1567-1588, 2021 09 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-34032254
10.
DDAP: docking domain affinity and biosynthetic pathway prediction tool for type I polyketide synthases.
Bioinformatics
; 36(3): 942-944, 2020 02 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31504190
11.
An overview of the cytochrome P450 enzymes that catalyze the same-site multistep oxidation reactions in biotechnologically relevant selected actinomycete strains.
Appl Microbiol Biotechnol
; 105(7): 2647-2661, 2021 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-33710358
12.
Exploring the molecular basis for substrate specificity in homologous macrolide biosynthetic cytochromes P450.
J Biol Chem
; 294(44): 15947-15961, 2019 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31488542
13.
Computational-Based Mechanistic Study and Engineering of Cytochrome P450 MycG for Selective Oxidation of 16-Membered Macrolide Antibiotics.
J Am Chem Soc
; 142(42): 17981-17988, 2020 10 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33030347
14.
Structure and Function of NzeB, a Versatile C-C and C-N Bond-Forming Diketopiperazine Dimerase.
J Am Chem Soc
; 142(41): 17413-17424, 2020 10 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-32786740
15.
Molecular Basis for Spirocycle Formation in the Paraherquamide Biosynthetic Pathway.
J Am Chem Soc
; 142(5): 2244-2252, 2020 02 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-31904957
16.
Flavin-Dependent Monooxygenases NotI and NotI' Mediate Spiro-Oxindole Formation in Biosynthesis of the Notoamides.
Chembiochem
; 21(17): 2449-2454, 2020 09 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32246875
17.
Structural basis of the Cope rearrangement and cyclization in hapalindole biogenesis.
Nat Chem Biol
; 14(4): 345-351, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29531360
18.
Stereoselective Synthesis of Baulamycin A.
J Org Chem
; 85(5): 3812-3823, 2020 03 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-31970985
19.
Structure of a modular polyketide synthase.
Nature
; 510(7506): 512-7, 2014 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24965652
20.
Structural rearrangements of a polyketide synthase module during its catalytic cycle.
Nature
; 510(7506): 560-4, 2014 Jun 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-24965656