RESUMO
The IntAct molecular interaction database (https://www.ebi.ac.uk/intact) is a curated resource of molecular interactions, derived from the scientific literature and from direct data depositions. As of August 2021, IntAct provides more than one million binary interactions, curated by twelve global partners of the International Molecular Exchange consortium, for which the IntAct database provides a shared curation and dissemination platform. The IMEx curation policy has always emphasised a fine-grained data and curation model, aiming to capture the relevant experimental detail essential for the interpretation of the provided molecular interaction data. Here, we present recent curation focus and progress, as well as a completely redeveloped website which presents IntAct data in a much more user-friendly and detailed way.
Assuntos
Bases de Dados de Proteínas , Mapas de Interação de Proteínas/genética , Software , Humanos , Mapeamento de Interação de Proteínas/métodosRESUMO
The International Molecular Exchange (IMEx) Consortium provides scientists with a single body of experimentally verified protein interactions curated in rich contextual detail to an internationally agreed standard. In this update to the work of the IMEx Consortium, we discuss how this initiative has been working in practice, how it has ensured database sustainability, and how it is meeting emerging annotation challenges through the introduction of new interactor types and data formats. Additionally, we provide examples of how IMEx data are being used by biomedical researchers and integrated in other bioinformatic tools and resources.
Assuntos
Acesso à Informação , Bases de Dados Genéticas , Humanos , Disseminação de Informação , Cooperação InternacionalRESUMO
This report describes two lesions - one on the lower lip and another on the hard palate that were correctly diagnosed as a mucocele. The usual location of the mucocele is the lower lip but rare on the palate. The mucocele is one of the common lesions of the oral mucosa, mainly associated with the minor salivary glands. This case illustrates a common presentation of mucocele with respect to signs and symptoms, location and duration. The features of a variety of oral lesions are discussed in detail and compared to various lesions of the oral cavity which will help clinicians in establishing an appropriate differential diagnosis.