Detalhe da pesquisa
1.
Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.
Nature
; 535(7610): 148-52, 2016 07 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27362227
2.
Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKCδ Signaling Axis.
J Biol Chem
; 291(41): 21669-21681, 2016 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-27519412
3.
Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
Nature
; 461(7264): 614-20, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-19759537
4.
hnRNP U enhances caspase-9 splicing and is modulated by AKT-dependent phosphorylation of hnRNP L.
J Biol Chem
; 288(12): 8575-8584, 2013 Mar 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-23396972
5.
Characterization of eicosanoid synthesis in a genetic ablation model of ceramide kinase.
J Lipid Res
; 54(7): 1834-47, 2013 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-23576683
6.
Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters.
Bioorg Med Chem Lett
; 23(21): 5980-91, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24018190
7.
The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations.
Bioorg Med Chem Lett
; 23(21): 5992-6000, 2013 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24054120
8.
Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists.
ACS Med Chem Lett
; 14(12): 1692-1699, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38116445
9.
Metallofullerene-nanoplatform-delivered interstitial brachytherapy improved survival in a murine model of glioblastoma multiforme.
Bioconjug Chem
; 23(9): 1873-80, 2012 Sep 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-22881865
10.
Biocatalytic synthesis and structure elucidation of cyclized metabolites of the deacetylase inhibitor panobinostat (LBH589).
Drug Metab Dispos
; 40(5): 1041-50, 2012 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-22344701
11.
Structure of human tankyrase 1 in complex with small-molecule inhibitors PJ34 and XAV939.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 68(Pt 2): 115-8, 2012 Feb 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22297980
12.
Metallofullerene-based nanoplatform for brain tumor brachytherapy and longitudinal imaging in a murine orthotopic xenograft model.
Radiology
; 261(1): 136-43, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21813738
13.
Potent and selective 2-naphthylsulfonamide substituted hydroxamic acid inhibitors of matrix metalloproteinase-13.
Bioorg Med Chem Lett
; 21(21): 6440-5, 2011 Nov 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21937229
14.
The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors.
Bioorg Med Chem Lett
; 21(16): 4909-12, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21742496
15.
Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors.
Bioorg Med Chem
; 19(15): 4626-34, 2011 Aug 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21723733
16.
In vitro and in vivo studies of single-walled carbon nanohorns with encapsulated metallofullerenes and exohedrally functionalized quantum dots.
Nano Lett
; 10(8): 2843-8, 2010 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-20698597
17.
Encapsulation of a radiolabeled cluster inside a fullerene cage, (177)Lu(x)Lu((3-x))N@C(80): an interleukin-13-conjugated radiolabeled metallofullerene platform.
J Am Chem Soc
; 132(14): 4980-1, 2010 Apr 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-20307100
18.
The Shock Index is not accurate at predicting outcomes in patients with upper gastrointestinal bleeding.
Aliment Pharmacol Ther
; 51(2): 253-260, 2020 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-31642558
19.
Evolution of Novartis' Small Molecule Screening Deck Design.
J Med Chem
; 63(23): 14425-14447, 2020 12 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-33140646
20.
Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.
J Med Chem
; 63(22): 13578-13594, 2020 11 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-32910655