Detalhe da pesquisa
1.
A Pilot Study to Assess the Suitability of Riboflavin as A Surrogate Marker of Breast Cancer Resistance Protein (BCRP) in Healthy Participants.
J Pharmacol Exp Ther
; 2024 Jan 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-38296646
2.
Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein-Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo.
Drug Metab Dispos
; 51(7): 851-861, 2023 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-37055191
3.
Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions.
Pharm Res
; 40(11): 2567-2584, 2023 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-37523014
4.
Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.
Bioorg Med Chem Lett
; 88: 129280, 2023 05 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37054759
5.
Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
J Pharmacol Exp Ther
; 376(1): 29-39, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-33127749
6.
Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
Bioorg Med Chem Lett
; 51: 128376, 2021 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34560263
7.
Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression.
J Pharmacol Exp Ther
; 375(1): 139-151, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32719071
8.
Detection of Weak Organic Anion-Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans.
Drug Metab Dispos
; 48(10): 841-848, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32723847
9.
Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.
Drug Metab Dispos
; 48(8): 724-734, 2020 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-32482623
10.
Enhanced and Persistent Inhibition of Organic Cation Transporter 1 Activity by Preincubation of Cyclosporine A.
Drug Metab Dispos
; 47(11): 1352-1360, 2019 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-31427432
11.
Dissecting the Contribution of OATP1B1 to Hepatic Uptake of Statins Using the OATP1B1 Selective Inhibitor Estropipate.
Mol Pharm
; 16(6): 2342-2353, 2019 06 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31039308
12.
Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.
Mol Pharm
; 16(9): 4065-4076, 2019 09 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-31335150
13.
Identification of novel glutathione conjugates of terbinafine in liver microsomes and hepatocytes across species.
Xenobiotica
; 49(12): 1403-1413, 2019 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-30747549
14.
Preclinical Characterization of (R)-3-((3S,4S)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate N-Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.
J Pharmacol Exp Ther
; 363(3): 377-393, 2017 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-28954811
15.
Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.
Drug Metab Dispos
; 45(10): 1049-1059, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28646080
16.
Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective.
Drug Metab Dispos
; 44(10): 1720-30, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27422672
17.
Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective.
Drug Metab Dispos
; 44(8): 1399-423, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-27052879
18.
Expression and characterization of cynomolgus monkey cytochrome CYP3A4 in a novel human embryonic kidney cell-based mammalian system.
Drug Metab Dispos
; 42(3): 369-76, 2014 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-24335510
19.
Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers.
Proc Natl Acad Sci U S A
; 108(37): 15366-71, 2011 Sep 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-21896751
20.
Evaluation of pregnane X receptor (PXR)-mediated CYP3A4 drug-drug interactions in drug development.
Drug Metab Rev
; 45(1): 3-14, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23330538