Detalhe da pesquisa
1.
Analysis of coordinated NMR chemical shifts to map allosteric regulatory networks in proteins.
Methods
; 209: 40-47, 2023 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-36535575
2.
Substrate-independent activation pathways of the CRISPR-Cas9 HNH nuclease.
Biophys J
; 122(24): 4635-4644, 2023 12 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-37936350
3.
A topological data analytic approach for discovering biophysical signatures in protein dynamics.
PLoS Comput Biol
; 18(5): e1010045, 2022 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35500014
4.
Structural Basis for Reduced Dynamics of Three Engineered HNH Endonuclease Lys-to-Ala Mutants for the Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-Associated 9 (CRISPR/Cas9) Enzyme.
Biochemistry
; 61(9): 785-794, 2022 05 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-35420793
5.
The N-terminus of MIF regulates the dynamic profile of residues involved in CD74 activation.
Biophys J
; 120(18): 3893-3900, 2021 09 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34437846
6.
Allosteric Motions of the CRISPR-Cas9 HNH Nuclease Probed by NMR and Molecular Dynamics.
J Am Chem Soc
; 142(3): 1348-1358, 2020 01 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-31885264
7.
High-fidelity, hyper-accurate, and evolved mutants rewire atomic-level communication in CRISPR-Cas9.
Sci Adv
; 10(10): eadl1045, 2024 Mar 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-38446895
8.
High-Fidelity, Hyper-Accurate, and Evolved Mutants Rewire Atomic Level Communication in CRISPR-Cas9.
bioRxiv
; 2023 Aug 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-37662375
9.
Redox-dependent structure and dynamics of macrophage migration inhibitory factor reveal sites of latent allostery.
Structure
; 30(6): 840-850.e6, 2022 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-35381187
10.
A Cysteine Variant at an Allosteric Site Alters MIF Dynamics and Biological Function in Homo- and Heterotrimeric Assemblies.
Front Mol Biosci
; 9: 783669, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35252348
11.
Twisting and swiveling domain motions in Cas9 to recognize target DNA duplexes, make double-strand breaks, and release cleaved duplexes.
Front Mol Biosci
; 9: 1072733, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-36699705
12.
Principles of target DNA cleavage and the role of Mg2+ in the catalysis of CRISPR-Cas9.
Nat Catal
; 5(10): 912-922, 2022 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-36778082
13.
1H, 13C, 15 N backbone resonance assignment of the recognition lobe subdomain 3 (Rec3) from Streptococcus pyogenes CRISPR-Cas9.
Biomol NMR Assign
; 15(1): 25-28, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-32935194
14.
High-Throughput Screening of a Functional Human CXCL12-CXCR4 Signaling Axis in a Genetically Modified S. cerevisiae: Discovery of a Novel Up-Regulator of CXCR4 Activity.
Front Mol Biosci
; 7: 164, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32766282
15.
Regulation of MIF Enzymatic Activity by an Allosteric Site at the Central Solvent Channel.
Cell Chem Biol
; 27(6): 740-750.e5, 2020 06 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32433911
16.
NMR and computational methods for molecular resolution of allosteric pathways in enzyme complexes.
Biophys Rev
; 12(1): 155-174, 2020 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-31838649