1.
Bull Exp Biol Med
; 150(4): 436-9, 2011 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22268037
RESUMO
We demonstrated an increase in glutamate neurocytotoxicity in cultured cerebellar cells from rat pups subjected to lead poisoning during the prenatal development or early lactation period. The toxic effect of glutamate was weaker, if lead was applied in combination with antioxidant comenic acid. These data are discussed in view of practical use of comenic acid for the therapy of the brain tissues subjected to lead poisoning.
Assuntos
Ácidos Carboxílicos/farmacologia , Glutamatos/toxicidade , Intoxicação do Sistema Nervoso por Chumbo/tratamento farmacológico , Neurônios/efeitos dos fármacos , Fármacos Neuroprotetores/farmacologia , Pironas/farmacologia , Animais , Animais Recém-Nascidos , Encéfalo/efeitos dos fármacos , Encéfalo/metabolismo , Encéfalo/patologia , Células Cultivadas , Feminino , Neurônios/metabolismo , Neurônios/patologia , Gravidez , Ratos , Ratos Wistar
2.
Bull Exp Biol Med
; 138(3): 262-3, 2004 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15665919
RESUMO
Addition of green tea extract in concentrations of 0.004-0.006% to the nutrient medium markedly stimulated the growth of spinal ganglion neurites of 1-2-day-old rats.