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1.
J Ethnopharmacol ; 111(2): 197-201, 2007 May 04.
Artigo em Inglês | MEDLINE | ID: mdl-17210236

RESUMO

Essential oils obtained from leaves of 29 medicinal plants commonly used in Brazil were screened against 13 different Escherichia coli serotypes. The oils were obtained by water-distillation using a Clevenger-type system and their minimal inhibitory concentration (MIC) were determined by microdilution method. Essential oil from Cymbopogon martinii exhibited a broad inhibition spectrum, presenting strong activity (MIC between 100 and 500 microg/mL) against 10 out of 13 Escherichia coli serotypes: three enterotoxigenic, two enteropathogenic, three enteroinvasive and two shiga-toxin producers. C. winterianus inhibited strongly two enterotoxigenic, one enteropathogenic, one enteroinvasive and one shiga-toxin producer serotypes. Aloysia triphylla also shows good potential to kill Escherichia coli with moderate to strong inhibition. Other essential oils showed antimicrobial properties, however with a more restricted action against the serotypes studied. Chemical analysis of Cymbopogon martinii essential oil performed by gas chromatography (GC) and gas chromatography/mass spectrometry (GC-MS) showed the presence of compounds with known antimicrobial activity, including geraniol, geranyl acetate and trans-cariophyllene, which tested separately, indicated geraniol as antimicrobial active compound. The significant antibacterial activity of Cymbopogon martinii oil suggests that they could serve as a source for compounds with therapeutic potential.


Assuntos
Anti-Infecciosos/farmacologia , Cymbopogon/química , Escherichia coli/efeitos dos fármacos , Etnofarmacologia , Medicina Tradicional , Óleos Voláteis/farmacologia , Óleos de Plantas/farmacologia , Plantas Medicinais/química , Acetatos/química , Acetatos/farmacologia , Monoterpenos Acíclicos , Anti-Infecciosos/análise , Anti-Infecciosos/isolamento & purificação , Brasil , Cromatografia Gasosa , Cymbopogon/anatomia & histologia , Escherichia coli/classificação , Escherichia coli/patogenicidade , Cromatografia Gasosa-Espectrometria de Massas , Testes de Sensibilidade Microbiana , Óleos Voláteis/análise , Óleos Voláteis/isolamento & purificação , Folhas de Planta/química , Óleos de Plantas/análise , Óleos de Plantas/isolamento & purificação , Sorotipagem , Terpenos/química , Terpenos/farmacologia
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