Detalhe da pesquisa
1.
The discovery and evaluation of [18F]BMS-986229, a novel macrocyclic peptide PET radioligand for the measurement of PD-L1 expression and in-vivo PD-L1 target engagement.
Eur J Nucl Med Mol Imaging
; 51(4): 978-990, 2024 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-38049658
2.
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Bioorg Med Chem
; 25(20): 5490-5505, 2017 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28818462
3.
Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.
Drug Metab Dispos
; 44(8): 1332-1340, 2016 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-26961241
4.
Development of a high-throughput mass spectrometry based analytical method to support an in vitro OATP1B1 inhibition screening assay.
Rapid Commun Mass Spectrom
; 30(15): 1787-96, 2016 08 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27426455
5.
Drug-induced perturbations of the bile acid pool, cholestasis, and hepatotoxicity: mechanistic considerations beyond the direct inhibition of the bile salt export pump.
Drug Metab Dispos
; 42(4): 566-74, 2014 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-24115749
6.
Evaluation of organic anion transporting polypeptide 1B1 and 1B3 humanized mice as a translational model to study the pharmacokinetics of statins.
Drug Metab Dispos
; 42(8): 1301-13, 2014 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-24855184
7.
Application of an in vitro OAT assay in drug design and optimization of renal clearance.
Xenobiotica
; 44(7): 657-65, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24417751
8.
Development, Characterization, and Radiation Dosimetry Studies of 18F-BMS-986229, a 18F-Labeled PD-L1 Macrocyclic Peptide PET Tracer.
Mol Imaging Biol
; 26(2): 301-309, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38123744
9.
Late intervention with a myeloperoxidase inhibitor stops progression of experimental chronic obstructive pulmonary disease.
Am J Respir Crit Care Med
; 185(1): 34-43, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21997333
10.
Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.
Toxicol Sci
; 194(2): 235-245, 2023 07 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-37261863
11.
The development, characterization, and application of an OATP1B1 inhibition assay in drug discovery.
Drug Metab Dispos
; 40(8): 1641-8, 2012 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-22587986
12.
Discovery of BMS-986339, a Pharmacologically Differentiated Farnesoid X Receptor Agonist for the Treatment of Nonalcoholic Steatohepatitis.
J Med Chem
; 65(13): 8948-8960, 2022 07 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-35704802
13.
Discovery of BMS-986318, a Potent Nonbile Acid FXR Agonist for the Treatment of Nonalcoholic Steatohepatitis.
ACS Med Chem Lett
; 12(9): 1413-1420, 2021 Sep 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-34531950
14.
Discovery of an Oxycyclohexyl Acid Lysophosphatidic Acid Receptor 1 (LPA1) Antagonist BMS-986278 for the Treatment of Pulmonary Fibrotic Diseases.
J Med Chem
; 64(21): 15549-15581, 2021 11 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34709814
15.
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 62(2): 831-856, 2019 01 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-30576602
16.
Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors.
ACS Med Chem Lett
; 9(12): 1217-1222, 2018 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-30613329
17.
The pivotal role of hepatocytes in drug discovery.
Chem Biol Interact
; 168(1): 2-15, 2007 May 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-17208208
18.
Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor.
ACS Med Chem Lett
; 8(7): 771-774, 2017 Jul 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-28740615
19.
Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 60(6): 2513-2525, 2017 03 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28234467
20.
The discovery of a pan-genotypic, primer grip inhibitor of HCV NS5B polymerase.
Medchemcomm
; 8(4): 796-806, 2017 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30108798