Detalhe da pesquisa
1.
Phase 1, single-dose study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of etelcalcetide in pediatric patients with secondary hyperparathyroidism receiving hemodialysis.
Pediatr Nephrol
; 36(1): 133-142, 2021 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-32647975
2.
Bridging adults and paediatrics with secondary hyperparathyroidism receiving haemodialysis: a pharmacokinetic-pharmacodynamic analysis of cinacalcet.
Br J Clin Pharmacol
; 85(6): 1312-1325, 2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30756425
3.
An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to < 6 years with chronic kidney disease receiving dialysis.
Pediatr Nephrol
; 34(1): 145-154, 2019 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-30141180
4.
Correction to: An open-label, single-dose study to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of cinacalcet in pediatric subjects aged 28 days to < 6 years with chronic kidney disease receiving dialysis.
Pediatr Nephrol
; 34(4): 739-740, 2019 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-30536181
5.
An open-label study in healthy men to evaluate the risk of seminal fluid transmission of denosumab to pregnant partners.
Br J Clin Pharmacol
; 81(2): 362-9, 2016 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-26447647
6.
Pharmacokinetic and pharmacodynamic relationship of AMG 811, an anti-IFN-γ IgG1 monoclonal antibody, in patients with systemic lupus erythematosus.
Pharm Res
; 32(2): 640-53, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25213774
7.
The pharmacokinetics and pharmacodynamics of denosumab in patients with advanced solid tumours and bone metastases: a systematic review.
Br J Clin Pharmacol
; 78(3): 477-87, 2014 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-24548274
8.
Pharmacokinetic Drug-Drug Interaction Study of Omecamtiv Mecarbil With Omeprazole, a Proton Pump Inhibitor, in Healthy Subjects.
Clin Pharmacol Drug Dev
; 11(1): 129-133, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-34272833
9.
Pharmacokinetic Drug-Drug Interaction Study of Omecamtiv Mecarbil With Amiodarone and Digoxin in Healthy Subjects.
Clin Pharmacol Drug Dev
; 11(3): 388-396, 2022 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-34634185
10.
Pharmacokinetics, Pharmacodynamics, and Tolerability of Olpasiran in Healthy Japanese and Non-Japanese Participants: Results from a Phase I, Single-dose, Open-label Study.
Clin Ther
; 44(9): 1237-1247, 2022 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35963802
11.
Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a).
Nat Med
; 28(1): 96-103, 2022 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-35027752
12.
Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study.
Lancet Oncol
; 11(3): 275-80, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-20149736
13.
Evaluation of drug-drug interaction potential between omecamtiv mecarbil and rosuvastatin, a BCRP substrate, with a clinical study in healthy subjects and using a physiologically-based pharmacokinetic model.
Clin Transl Sci
; 14(6): 2510-2520, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34415673
14.
A Phase I, Multiple-Dose, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate Pharmacokinetics, Safety, and Tolerability of Etelcalcetide Administered Intravenously to Chinese Patients With Chronic Kidney Disease Undergoing Hemodialysis.
Clin Ther
; 43(11): 2013-2023, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-34774334
15.
Phase 1 trial of denosumab safety, pharmacokinetics, and pharmacodynamics in Japanese women with breast cancer-related bone metastases.
Cancer Sci
; 99(6): 1237-42, 2008 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-18429961
16.
Safety, pharmacokinetics and pharmacodynamics of AMG 811, an anti-interferon-γ monoclonal antibody, in SLE subjects without or with lupus nephritis.
Lupus Sci Med
; 4(1): e000226, 2017.
Artigo
em Inglês
| MEDLINE | ID: mdl-29018537
17.
Quantitative pharmacology of denosumab in patients with bone metastases from solid tumors.
J Clin Pharmacol
; 55 Suppl 3: S85-92, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25707967
18.
Blockade of interferon-γ normalizes interferon-regulated gene expression and serum CXCL10 levels in patients with systemic lupus erythematosus.
Arthritis Rheumatol
; 67(10): 2713-22, 2015 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-26138472
19.
Denosumab dose selection for patients with bone metastases from solid tumors.
Clin Cancer Res
; 18(9): 2648-57, 2012 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22394983
20.
Population pharmacokinetic analysis of denosumab in patients with bone metastases from solid tumours.
Clin Pharmacokinet
; 51(4): 247-60, 2012 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-22420579