Detalhe da pesquisa
1.
Synthesis and biological evaluation of N-cyanoalkyl-, N-aminoalkyl-, and N-guanidinoalkyl-substituted 4-aminoquinoline derivatives as potent, selective, brain permeable antitrypanosomal agents.
Bioorg Med Chem
; 24(21): 5162-5171, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27591008
2.
Design, synthesis and biological evaluation of N-methyl-N-[(1,2,3-triazol-4-yl)alkyl]propargylamines as novel monoamine oxidase B inhibitors.
Bioorg Med Chem
; 24(20): 4835-4854, 2016 10 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-27396685
3.
Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity.
Bioorg Med Chem
; 23(16): 5156-67, 2015 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-25678015
4.
Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound.
Molecules
; 20(3): 4492-515, 2015 Mar 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-25764491
5.
Synthesis and antiprotozoal activity of oligomethylene- and p-phenylene-bis(methylene)-linked bis(+)-huprines.
Bioorg Med Chem Lett
; 24(23): 5435-8, 2014 Dec 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25454267
6.
Expanding the multipotent profile of huprine-tacrine heterodimers as disease-modifying anti-Alzheimer agents.
Neurodegener Dis
; 10(1-4): 96-9, 2012.
Artigo
em Inglês
| MEDLINE | ID: mdl-22236498
7.
First homology model of Plasmodium falciparum glucose-6-phosphate dehydrogenase: Discovery of selective substrate analog-based inhibitors as novel antimalarial agents.
Eur J Med Chem
; 146: 108-122, 2018 Feb 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29407943
8.
Rhein-Huprine Derivatives Reduce Cognitive Impairment, Synaptic Failure and Amyloid Pathology in AßPPswe/PS-1 Mice of Different Ages.
Curr Alzheimer Res
; 13(9): 1017-29, 2016.
Artigo
em Inglês
| MEDLINE | ID: mdl-26502813
9.
Novel Levetiracetam Derivatives That Are Effective against the Alzheimer-like Phenotype in Mice: Synthesis, in Vitro, ex Vivo, and in Vivo Efficacy Studies.
J Med Chem
; 58(15): 6018-32, 2015 Aug 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26181606
10.
Multicomponent reaction-based synthesis and biological evaluation of tricyclic heterofused quinolines with multi-trypanosomatid activity.
Eur J Med Chem
; 105: 120-37, 2015 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-26479031
11.
Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents.
J Med Chem
; 57(6): 2549-67, 2014 Mar 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-24568372
12.
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases.
J Med Chem
; 55(2): 661-9, 2012 Jan 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-22185619