Detalhe da pesquisa
1.
Preclinical Evaluation of Azabenzimidazole-Based PET Radioligands for γ-8 Dependent Transmembrane AMPA Receptor Regulatory Protein Imaging.
Chembiochem
; 25(6): e202300813, 2024 03 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38227784
2.
Discovery of novel indazole derivatives as SOS1 agonists that activate KRAS signaling.
Bioorg Med Chem
; 93: 117457, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37688996
3.
Synthesis and biological evaluation of azole-diphenylpyrimidine derivatives (AzDPPYs) as potent T790M mutant form of epidermal growth factor receptor inhibitors.
Bioorg Med Chem
; 24(21): 5505-5512, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27634676
4.
Novel Selective and Potent EGFR Inhibitor that Overcomes T790M-Mediated Resistance in Non-Small Cell Lung Cancer.
Molecules
; 21(11)2016 Nov 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-27827863
5.
Improving automatic segmentation of liver tumor images using a deep learning model.
Heliyon
; 10(7): e28538, 2024 Apr 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-38571625
6.
The LINC01176-miR-218-5p-IL-36G Network is Responsible for the Pathogenesis of Psoriasis by Promoting Inflammation.
Clin Cosmet Investig Dermatol
; 17: 1-12, 2024.
Artigo
em Inglês
| MEDLINE | ID: mdl-38193028
7.
Preclinical Evaluation of Novel Positron Emission Tomography (PET) Probes for Imaging Leucine-Rich Repeat Kinase 2 (LRRK2).
J Med Chem
; 67(4): 2559-2569, 2024 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-38305157
8.
Simulation study on assist-as-needed control of a rehabilitation robotic walker.
Technol Health Care
; 31(S1): 293-302, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37066930
9.
Identification of novel Pyrrolo[2,3-d]Pyrimidine-based KRAS G12C inhibitors with anticancer effects.
Eur J Med Chem
; 245(Pt 1): 114907, 2023 Jan 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-36395648
10.
First description of males of Ensiferothrips wallacei Mound amp; Tree (Thripidae: Dendrothripinae) with variation in fore wing setae.
Zootaxa
; 5174(4): 444-446, 2022 Aug 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-36095388
11.
Synthesis and evaluation of imidazo[1,2-a]pyrazine derivatives as small molecule Gαq/11 inhibitors against uveal melanoma.
Eur J Med Chem
; 239: 114520, 2022 Sep 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-35716516
12.
Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma.
Acta Pharm Sin B
; 12(8): 3326-3340, 2022 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-35967274
13.
Discovery and Structural Optimization of Toddacoumalone Derivatives as Novel PDE4 Inhibitors for the Topical Treatment of Psoriasis.
J Med Chem
; 65(5): 4238-4254, 2022 03 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-35188767
14.
Structure-based optimization of Toddacoumalone as highly potent and selective PDE4 inhibitors with anti-inflammatory effects.
Biochem Pharmacol
; 202: 115123, 2022 08.
Artigo
em Inglês
| MEDLINE | ID: mdl-35688178
15.
Targeting mutated GTPase KRAS in tumor therapies.
Eur J Med Chem
; 226: 113816, 2021 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-34520956
16.
Demethylative Alkylation of Methionine Residue by Employing the Sulfonium as the Key Intermediate.
Org Lett
; 23(21): 8543-8548, 2021 11 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-34669410
17.
Design, Synthesis, and Evaluation of Small Molecule Gαq/11 Protein Inhibitors for the Treatment of Uveal Melanoma.
J Med Chem
; 64(6): 3131-3152, 2021 03 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-33715360
18.
Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies.
Acta Pharm Sin B
; 11(1): 13-29, 2021 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-33532178
19.
Cleavable and tunable cysteine-specific arylation modification with aryl thioethers.
Chem Sci
; 12(14): 5209-5215, 2021 Feb 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-34168774
20.
[Effect of cardiopulmonary bypass on the expression of survivin in neutrophils].
Zhonghua Yi Xue Za Zhi
; 90(23): 1618-21, 2010 Jun 15.
Artigo
em Zh
| MEDLINE | ID: mdl-20979750