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1.
Pediatr Dermatol ; 34(1): 58-63, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27873356

RESUMO

BACKGROUND/OBJECTIVES: Little information is available on the prevalence and clinical aspects of nail involvement in children with psoriasis. The objective of this study was to evaluate the prevalence and clinical aspects of and the risk factors for nail involvement in French children with psoriasis. METHODS: We performed a multicenter, cross-sectional study in 23 French dermatology centers. All children seen during the 1-year study were systematically included. Clinical features of the nails were collected. Association with clinical aspects of the disease and comorbidities were evaluated. RESULTS: Of 313 children with psoriasis (mean age 9.1 ± 4.2 yrs; 149 boys, 164 girls), 31.1% had familial psoriasis and 30% had severe psoriasis. The mean age at onset was 6.1 ± 3.7 years. Nails were involved in 32.3% of children. The main clinical aspects were pitting (69.1%) for fingernails and onycholysis (40.0%) and pachyonychia (27.5%) for toenails. All of the fingers were involved at similar frequencies, whereas the big toe was involved twice as often as the others (p < 0.005). Nail involvement was associated with male sex (p < 0.001), palmoplantar psoriatic (p < 0.001), severity of disease (p = 0.003), and psoriatic arthritis (p = 0.03). CONCLUSION: The prevalence of nail involvement was 32.3% in children with psoriasis. Clinical aspects in children are reported, as well as clinical associations. As in adults, nail psoriasis is closely associated with psoriatic arthritis.


Assuntos
Doenças da Unha/epidemiologia , Unhas/patologia , Psoríase/epidemiologia , Adolescente , Criança , Pré-Escolar , Estudos Transversais , Feminino , França/epidemiologia , Humanos , Masculino , Prevalência , Fatores de Risco
2.
Pediatr Dermatol ; 20(3): 249-53, 2003.
Artigo em Inglês | MEDLINE | ID: mdl-12787276

RESUMO

Focal dermal hypoplasia (FDH) or Goltz syndrome is a rare genodermatosis transmitted in a dominant, X-linked mode. It is characterized clinically by atrophic skin lesions, multiple mucocutaneous papillomas, hyperpigmented linear skin lesions, and several skeletal and visceral anomalies. We followed over several years a female patient with FDH, who had the characteristic atrophic cutaneous lesions and periorificial papillomas, who developed at the periphery of atrophic lesions peculiar lentigo-like pigmented macules. Immunohistologically, increased melanin deposits within the epidermis and the dermis were seen, produced by stimulated epidermal melanocytes expressing the HMB-45 antigen. These findings further support the contention that cutaneous lesions of FDH may be progressive, and provide a physiopathologic basis for understanding the hyperpigmented lesions of FDH.


Assuntos
Hipoplasia Dérmica Focal/patologia , Hiperpigmentação/patologia , Lentigo/patologia , Adolescente , Biópsia por Agulha , Feminino , Hipoplasia Dérmica Focal/complicações , Seguimentos , Humanos , Hiperpigmentação/complicações , Imuno-Histoquímica , Lentigo/complicações , Melanócitos/patologia , Medição de Risco , Índice de Gravidade de Doença
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